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Association between cardiovascular risk factors and colorectal cancer: A systematic review and meta-analysis of prospective cohort studies

BACKGROUND: Emerging data have suggested colorectal cancer (CRC) often coexists with cardiovascular diseases, but whether cardiovascular risk factors play a role in CRC remains unclear. We performed a systematic review and meta-analysis to better illustrate the associations between cardiovascular ri...

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Autores principales: Zhang, Chen, Cheng, Yunjiu, Luo, Dongling, Wang, Jinghua, Liu, Jianhua, Luo, Yujun, Zhou, Weijie, Zhuo, Zewei, Guo, Kehang, Zeng, Ruijie, Yang, Jun, Sha, Weihong, Chen, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102710/
https://www.ncbi.nlm.nih.gov/pubmed/33997727
http://dx.doi.org/10.1016/j.eclinm.2021.100794
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author Zhang, Chen
Cheng, Yunjiu
Luo, Dongling
Wang, Jinghua
Liu, Jianhua
Luo, Yujun
Zhou, Weijie
Zhuo, Zewei
Guo, Kehang
Zeng, Ruijie
Yang, Jun
Sha, Weihong
Chen, Hao
author_facet Zhang, Chen
Cheng, Yunjiu
Luo, Dongling
Wang, Jinghua
Liu, Jianhua
Luo, Yujun
Zhou, Weijie
Zhuo, Zewei
Guo, Kehang
Zeng, Ruijie
Yang, Jun
Sha, Weihong
Chen, Hao
author_sort Zhang, Chen
collection PubMed
description BACKGROUND: Emerging data have suggested colorectal cancer (CRC) often coexists with cardiovascular diseases, but whether cardiovascular risk factors play a role in CRC remains unclear. We performed a systematic review and meta-analysis to better illustrate the associations between cardiovascular risk factors and CRC. METHODS: We searched EMBASE, MEDLINE and Web of Science databases from inception up to June 14, 2020. Prospective cohort studies were included if they evaluated the association between at least one of cardiovascular risk factors and CRC incidence, containing sufficient data to obtain relative risk (RR) and 95% confidence interval (CI). We performed separate meta-analyses for each cardiovascular risk factor using random-effect model. PROSPERO registration number: CRD42020175537. FINDINGS: Data from 84 studies, reporting 52, 348, 827 individuals and 384, 973 incident cases were included in the analysis. Overall, the risk of CRC was 1.31(95% CI, 1.21–1.42) for obesity, 1.14 (95% CI, 1.09–1.20) for per 5 kg/m(2) increase in body mass index, 1.18 (95% CI, 1.14–1.23) for former smoker, 1.20 (95% CI, 1.11–1.30) for current smoker, 1.25 (95% CI, 1.16–1.35) for diabetes, 1.07 (95% CI, 1.02–1.12) for hypertension. The summary RRs of CRC for the highest versus lowest quartiles of total cholesterol, triglyceride, low-density lipoprotein were 1.12 (95% CI, 1.03–1.22), 1.18 (95% CI, 1.04–1.35), 0.85 (95% CI, 0.62–1.17) respectively and the pooled RR for the lowest versus highest quartile of high-density lipoprotein was 1.14 (95% CI, 1.02–1.28). INTERPRETATION: Unfavorable cardiovascular risk factors are associated with increased risk of CRC, which may provide novel insight into the screening strategies of CRC in patient with these risk factors.
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spelling pubmed-81027102021-05-14 Association between cardiovascular risk factors and colorectal cancer: A systematic review and meta-analysis of prospective cohort studies Zhang, Chen Cheng, Yunjiu Luo, Dongling Wang, Jinghua Liu, Jianhua Luo, Yujun Zhou, Weijie Zhuo, Zewei Guo, Kehang Zeng, Ruijie Yang, Jun Sha, Weihong Chen, Hao EClinicalMedicine Research Paper BACKGROUND: Emerging data have suggested colorectal cancer (CRC) often coexists with cardiovascular diseases, but whether cardiovascular risk factors play a role in CRC remains unclear. We performed a systematic review and meta-analysis to better illustrate the associations between cardiovascular risk factors and CRC. METHODS: We searched EMBASE, MEDLINE and Web of Science databases from inception up to June 14, 2020. Prospective cohort studies were included if they evaluated the association between at least one of cardiovascular risk factors and CRC incidence, containing sufficient data to obtain relative risk (RR) and 95% confidence interval (CI). We performed separate meta-analyses for each cardiovascular risk factor using random-effect model. PROSPERO registration number: CRD42020175537. FINDINGS: Data from 84 studies, reporting 52, 348, 827 individuals and 384, 973 incident cases were included in the analysis. Overall, the risk of CRC was 1.31(95% CI, 1.21–1.42) for obesity, 1.14 (95% CI, 1.09–1.20) for per 5 kg/m(2) increase in body mass index, 1.18 (95% CI, 1.14–1.23) for former smoker, 1.20 (95% CI, 1.11–1.30) for current smoker, 1.25 (95% CI, 1.16–1.35) for diabetes, 1.07 (95% CI, 1.02–1.12) for hypertension. The summary RRs of CRC for the highest versus lowest quartiles of total cholesterol, triglyceride, low-density lipoprotein were 1.12 (95% CI, 1.03–1.22), 1.18 (95% CI, 1.04–1.35), 0.85 (95% CI, 0.62–1.17) respectively and the pooled RR for the lowest versus highest quartile of high-density lipoprotein was 1.14 (95% CI, 1.02–1.28). INTERPRETATION: Unfavorable cardiovascular risk factors are associated with increased risk of CRC, which may provide novel insight into the screening strategies of CRC in patient with these risk factors. Elsevier 2021-03-18 /pmc/articles/PMC8102710/ /pubmed/33997727 http://dx.doi.org/10.1016/j.eclinm.2021.100794 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Zhang, Chen
Cheng, Yunjiu
Luo, Dongling
Wang, Jinghua
Liu, Jianhua
Luo, Yujun
Zhou, Weijie
Zhuo, Zewei
Guo, Kehang
Zeng, Ruijie
Yang, Jun
Sha, Weihong
Chen, Hao
Association between cardiovascular risk factors and colorectal cancer: A systematic review and meta-analysis of prospective cohort studies
title Association between cardiovascular risk factors and colorectal cancer: A systematic review and meta-analysis of prospective cohort studies
title_full Association between cardiovascular risk factors and colorectal cancer: A systematic review and meta-analysis of prospective cohort studies
title_fullStr Association between cardiovascular risk factors and colorectal cancer: A systematic review and meta-analysis of prospective cohort studies
title_full_unstemmed Association between cardiovascular risk factors and colorectal cancer: A systematic review and meta-analysis of prospective cohort studies
title_short Association between cardiovascular risk factors and colorectal cancer: A systematic review and meta-analysis of prospective cohort studies
title_sort association between cardiovascular risk factors and colorectal cancer: a systematic review and meta-analysis of prospective cohort studies
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102710/
https://www.ncbi.nlm.nih.gov/pubmed/33997727
http://dx.doi.org/10.1016/j.eclinm.2021.100794
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