Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?

Oxidative stress is a major component of cellular damage in T cells from patients with systemic lupus erythematosus (SLE) resulting amongst others in the generation of pathogenic Th17 cells. The NRF2/Keap1 pathway is the most important antioxidant system protecting cells from damage due to oxidative...

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Autores principales: Ohl, Kim, Tenbrock, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102865/
https://www.ncbi.nlm.nih.gov/pubmed/33968025
http://dx.doi.org/10.3389/fimmu.2021.633845
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author Ohl, Kim
Tenbrock, Klaus
author_facet Ohl, Kim
Tenbrock, Klaus
author_sort Ohl, Kim
collection PubMed
description Oxidative stress is a major component of cellular damage in T cells from patients with systemic lupus erythematosus (SLE) resulting amongst others in the generation of pathogenic Th17 cells. The NRF2/Keap1 pathway is the most important antioxidant system protecting cells from damage due to oxidative stress. Activation of NRF2 therefore seems to represent a putative therapeutic target in SLE, which is nevertheless challenged by several findings suggesting tissue and cell specific differences in the effect of NRF2 expression. This review focusses on the current understanding of oxidative stress in SLE T cells and its pathophysiologic and therapeutic implications.
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spelling pubmed-81028652021-05-08 Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat? Ohl, Kim Tenbrock, Klaus Front Immunol Immunology Oxidative stress is a major component of cellular damage in T cells from patients with systemic lupus erythematosus (SLE) resulting amongst others in the generation of pathogenic Th17 cells. The NRF2/Keap1 pathway is the most important antioxidant system protecting cells from damage due to oxidative stress. Activation of NRF2 therefore seems to represent a putative therapeutic target in SLE, which is nevertheless challenged by several findings suggesting tissue and cell specific differences in the effect of NRF2 expression. This review focusses on the current understanding of oxidative stress in SLE T cells and its pathophysiologic and therapeutic implications. Frontiers Media S.A. 2021-04-23 /pmc/articles/PMC8102865/ /pubmed/33968025 http://dx.doi.org/10.3389/fimmu.2021.633845 Text en Copyright © 2021 Ohl and Tenbrock https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ohl, Kim
Tenbrock, Klaus
Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?
title Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?
title_full Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?
title_fullStr Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?
title_full_unstemmed Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?
title_short Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?
title_sort oxidative stress in sle t cells, is nrf2 really the target to treat?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102865/
https://www.ncbi.nlm.nih.gov/pubmed/33968025
http://dx.doi.org/10.3389/fimmu.2021.633845
work_keys_str_mv AT ohlkim oxidativestressinsletcellsisnrf2reallythetargettotreat
AT tenbrockklaus oxidativestressinsletcellsisnrf2reallythetargettotreat

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