Cargando…
Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer
Macrophages are crucial innate immune cells that maintain tissue homeostasis and defend against pathogens; however, their infiltration into tumors has been associated with adverse outcomes. Tumor-associated macrophages (TAMs) represent a significant component of the inflammatory infiltrate in breast...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102870/ https://www.ncbi.nlm.nih.gov/pubmed/33968034 http://dx.doi.org/10.3389/fimmu.2021.643771 |
_version_ | 1783689194385702912 |
---|---|
author | Mehta, Anita K. Kadel, Sapana Townsend, Madeline G. Oliwa, Madisson Guerriero, Jennifer L. |
author_facet | Mehta, Anita K. Kadel, Sapana Townsend, Madeline G. Oliwa, Madisson Guerriero, Jennifer L. |
author_sort | Mehta, Anita K. |
collection | PubMed |
description | Macrophages are crucial innate immune cells that maintain tissue homeostasis and defend against pathogens; however, their infiltration into tumors has been associated with adverse outcomes. Tumor-associated macrophages (TAMs) represent a significant component of the inflammatory infiltrate in breast tumors, and extensive infiltration of TAMs has been linked to poor prognosis in breast cancer. Here, we detail how TAMs impede a productive tumor immunity cycle by limiting antigen presentation and reducing activation of cytotoxic T lymphocytes (CTLs) while simultaneously supporting tumor cell survival, angiogenesis, and metastasis. There is an urgent need to overcome TAM-mediated immune suppression for durable anti-tumor immunity in breast cancer. To date, failure to fully characterize TAM biology and classify multiple subsets has hindered advancement in therapeutic targeting. In this regard, the complexity of TAMs has recently taken center stage owing to their subset diversity and tightly regulated molecular and metabolic phenotypes. In this review, we reveal major gaps in our knowledge of the functional and phenotypic characterization of TAM subsets associated with breast cancer, before and after treatment. Future work to characterize TAM subsets, location, and crosstalk with neighboring cells will be critical to counteract TAM pro-tumor functions and to identify novel TAM-modulating strategies and combinations that are likely to enhance current therapies and overcome chemo- and immuno-therapy resistance. |
format | Online Article Text |
id | pubmed-8102870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81028702021-05-08 Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer Mehta, Anita K. Kadel, Sapana Townsend, Madeline G. Oliwa, Madisson Guerriero, Jennifer L. Front Immunol Immunology Macrophages are crucial innate immune cells that maintain tissue homeostasis and defend against pathogens; however, their infiltration into tumors has been associated with adverse outcomes. Tumor-associated macrophages (TAMs) represent a significant component of the inflammatory infiltrate in breast tumors, and extensive infiltration of TAMs has been linked to poor prognosis in breast cancer. Here, we detail how TAMs impede a productive tumor immunity cycle by limiting antigen presentation and reducing activation of cytotoxic T lymphocytes (CTLs) while simultaneously supporting tumor cell survival, angiogenesis, and metastasis. There is an urgent need to overcome TAM-mediated immune suppression for durable anti-tumor immunity in breast cancer. To date, failure to fully characterize TAM biology and classify multiple subsets has hindered advancement in therapeutic targeting. In this regard, the complexity of TAMs has recently taken center stage owing to their subset diversity and tightly regulated molecular and metabolic phenotypes. In this review, we reveal major gaps in our knowledge of the functional and phenotypic characterization of TAM subsets associated with breast cancer, before and after treatment. Future work to characterize TAM subsets, location, and crosstalk with neighboring cells will be critical to counteract TAM pro-tumor functions and to identify novel TAM-modulating strategies and combinations that are likely to enhance current therapies and overcome chemo- and immuno-therapy resistance. Frontiers Media S.A. 2021-04-23 /pmc/articles/PMC8102870/ /pubmed/33968034 http://dx.doi.org/10.3389/fimmu.2021.643771 Text en Copyright © 2021 Mehta, Kadel, Townsend, Oliwa and Guerriero. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Mehta, Anita K. Kadel, Sapana Townsend, Madeline G. Oliwa, Madisson Guerriero, Jennifer L. Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer |
title | Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer |
title_full | Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer |
title_fullStr | Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer |
title_full_unstemmed | Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer |
title_short | Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer |
title_sort | macrophage biology and mechanisms of immune suppression in breast cancer |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102870/ https://www.ncbi.nlm.nih.gov/pubmed/33968034 http://dx.doi.org/10.3389/fimmu.2021.643771 |
work_keys_str_mv | AT mehtaanitak macrophagebiologyandmechanismsofimmunesuppressioninbreastcancer AT kadelsapana macrophagebiologyandmechanismsofimmunesuppressioninbreastcancer AT townsendmadelineg macrophagebiologyandmechanismsofimmunesuppressioninbreastcancer AT oliwamadisson macrophagebiologyandmechanismsofimmunesuppressioninbreastcancer AT guerrierojenniferl macrophagebiologyandmechanismsofimmunesuppressioninbreastcancer |