LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway

OBJECTIVE: Adaptive rewiring of cancer energy metabolism has received increasing attention. By binding with LDLs, LDLRs make most of the circulating cholesterol available for cells to utilize. However, it remains unclear how LDLR works in HCC development by affecting cholesterol metabolism. METHODS:...

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Detalles Bibliográficos
Autores principales: Chen, Ziye, Chen, Lu, Sun, Bo, Liu, Dongming, He, Yuchao, Qi, Lisha, Li, Guangtao, Han, Zhiqiang, Zhan, Linlin, Zhang, Su, Zhu, Keyun, Luo, Yi, Chen, Liwei, Zhang, Ning, Guo, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102998/
https://www.ncbi.nlm.nih.gov/pubmed/33823318
http://dx.doi.org/10.1016/j.molmet.2021.101230

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