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Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia

Acute hypoxia (AH) is a challenge to the homeostasis of the cardiovascular system, especially during exercise. Research in this area is scarce. We aimed to ascertain whether echocardiographic, Doppler, and tissue Doppler measures were able to detect changes in systolic and diastolic functions during...

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Autores principales: Magnani, Sara, Mulliri, Gabriele, Roberto, Silvana, Sechi, Fabio, Ghiani, Giovanna, Sainas, Gianmarco, Nughedu, Giorgio, Vargiu, Romina, Bassareo, Pier Paolo, Crisafulli, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103167/
https://www.ncbi.nlm.nih.gov/pubmed/33967823
http://dx.doi.org/10.3389/fphys.2021.650696
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author Magnani, Sara
Mulliri, Gabriele
Roberto, Silvana
Sechi, Fabio
Ghiani, Giovanna
Sainas, Gianmarco
Nughedu, Giorgio
Vargiu, Romina
Bassareo, Pier Paolo
Crisafulli, Antonio
author_facet Magnani, Sara
Mulliri, Gabriele
Roberto, Silvana
Sechi, Fabio
Ghiani, Giovanna
Sainas, Gianmarco
Nughedu, Giorgio
Vargiu, Romina
Bassareo, Pier Paolo
Crisafulli, Antonio
author_sort Magnani, Sara
collection PubMed
description Acute hypoxia (AH) is a challenge to the homeostasis of the cardiovascular system, especially during exercise. Research in this area is scarce. We aimed to ascertain whether echocardiographic, Doppler, and tissue Doppler measures were able to detect changes in systolic and diastolic functions during the recovery after mild exercise in AH. Twelve healthy males (age 33.5 ± 4.8 years) completed a cardiopulmonary test on an electromagnetically braked cycle-ergometer to determine their maximum workload (W(max)). On separate days, participants performed randomly assigned two exercise sessions consisting in 3 min pedalling at 30% of W(max): (1) one test was conducted in normoxia (NORMO) and (2) one in normobaric hypoxia with FiO(2) set to 13.5% (HYPO). Hemodynamics were assessed with an echocardiographic system. The main result was that the HYPO session increased parameters related to myocardial contractility such as pre-ejection period and systolic myocardial velocity with respect to the NORMO test. Moreover, the HYPO test enhanced early transmitral filling peak velocities. No effects were detected for left ventricular volumes, as end-diastolic, end-systolic, and stroke volume were similar between the NORMO and the HYPO test. Results of the present investigation support the hypothesis that a brief, mild exercise bout in acute normobaric hypoxia does not impair systolic or diastolic functions. Rather, it appears that stroke volume is well preserved and that systolic and early diastolic functions are enhanced by exercise in hypoxia.
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spelling pubmed-81031672021-05-08 Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia Magnani, Sara Mulliri, Gabriele Roberto, Silvana Sechi, Fabio Ghiani, Giovanna Sainas, Gianmarco Nughedu, Giorgio Vargiu, Romina Bassareo, Pier Paolo Crisafulli, Antonio Front Physiol Physiology Acute hypoxia (AH) is a challenge to the homeostasis of the cardiovascular system, especially during exercise. Research in this area is scarce. We aimed to ascertain whether echocardiographic, Doppler, and tissue Doppler measures were able to detect changes in systolic and diastolic functions during the recovery after mild exercise in AH. Twelve healthy males (age 33.5 ± 4.8 years) completed a cardiopulmonary test on an electromagnetically braked cycle-ergometer to determine their maximum workload (W(max)). On separate days, participants performed randomly assigned two exercise sessions consisting in 3 min pedalling at 30% of W(max): (1) one test was conducted in normoxia (NORMO) and (2) one in normobaric hypoxia with FiO(2) set to 13.5% (HYPO). Hemodynamics were assessed with an echocardiographic system. The main result was that the HYPO session increased parameters related to myocardial contractility such as pre-ejection period and systolic myocardial velocity with respect to the NORMO test. Moreover, the HYPO test enhanced early transmitral filling peak velocities. No effects were detected for left ventricular volumes, as end-diastolic, end-systolic, and stroke volume were similar between the NORMO and the HYPO test. Results of the present investigation support the hypothesis that a brief, mild exercise bout in acute normobaric hypoxia does not impair systolic or diastolic functions. Rather, it appears that stroke volume is well preserved and that systolic and early diastolic functions are enhanced by exercise in hypoxia. Frontiers Media S.A. 2021-04-23 /pmc/articles/PMC8103167/ /pubmed/33967823 http://dx.doi.org/10.3389/fphys.2021.650696 Text en Copyright © 2021 Magnani, Mulliri, Roberto, Sechi, Ghiani, Sainas, Nughedu, Vargiu, Bassareo and Crisafulli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Magnani, Sara
Mulliri, Gabriele
Roberto, Silvana
Sechi, Fabio
Ghiani, Giovanna
Sainas, Gianmarco
Nughedu, Giorgio
Vargiu, Romina
Bassareo, Pier Paolo
Crisafulli, Antonio
Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia
title Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia
title_full Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia
title_fullStr Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia
title_full_unstemmed Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia
title_short Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia
title_sort systolic and diastolic functions after a brief acute bout of mild exercise in normobaric hypoxia
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103167/
https://www.ncbi.nlm.nih.gov/pubmed/33967823
http://dx.doi.org/10.3389/fphys.2021.650696
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