Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress

Mitochondria are known to generate approximately 90% of cellular reactive oxygen species (ROS). The imbalance between mitochondrial reactive oxygen species (mtROS) production and removal due to overproduction of ROS and/or decreased antioxidants defense activity results in oxidative stress (OS), whi...

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Autores principales: Tirichen, Hasna, Yaigoub, Hasnaa, Xu, Weiwei, Wu, Changxin, Li, Rongshan, Li, Yafeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103168/
https://www.ncbi.nlm.nih.gov/pubmed/33967820
http://dx.doi.org/10.3389/fphys.2021.627837
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author Tirichen, Hasna
Yaigoub, Hasnaa
Xu, Weiwei
Wu, Changxin
Li, Rongshan
Li, Yafeng
author_facet Tirichen, Hasna
Yaigoub, Hasnaa
Xu, Weiwei
Wu, Changxin
Li, Rongshan
Li, Yafeng
author_sort Tirichen, Hasna
collection PubMed
description Mitochondria are known to generate approximately 90% of cellular reactive oxygen species (ROS). The imbalance between mitochondrial reactive oxygen species (mtROS) production and removal due to overproduction of ROS and/or decreased antioxidants defense activity results in oxidative stress (OS), which leads to oxidative damage that affects several cellular components such as lipids, DNA, and proteins. Since the kidney is a highly energetic organ, it is more vulnerable to damage caused by OS and thus its contribution to the development and progression of chronic kidney disease (CKD). This article aims to review the contribution of mtROS and OS to CKD progression and kidney function deterioration.
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spelling pubmed-81031682021-05-08 Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress Tirichen, Hasna Yaigoub, Hasnaa Xu, Weiwei Wu, Changxin Li, Rongshan Li, Yafeng Front Physiol Physiology Mitochondria are known to generate approximately 90% of cellular reactive oxygen species (ROS). The imbalance between mitochondrial reactive oxygen species (mtROS) production and removal due to overproduction of ROS and/or decreased antioxidants defense activity results in oxidative stress (OS), which leads to oxidative damage that affects several cellular components such as lipids, DNA, and proteins. Since the kidney is a highly energetic organ, it is more vulnerable to damage caused by OS and thus its contribution to the development and progression of chronic kidney disease (CKD). This article aims to review the contribution of mtROS and OS to CKD progression and kidney function deterioration. Frontiers Media S.A. 2021-04-23 /pmc/articles/PMC8103168/ /pubmed/33967820 http://dx.doi.org/10.3389/fphys.2021.627837 Text en Copyright © 2021 Tirichen, Yaigoub, Xu, Wu, Li and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Tirichen, Hasna
Yaigoub, Hasnaa
Xu, Weiwei
Wu, Changxin
Li, Rongshan
Li, Yafeng
Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress
title Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress
title_full Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress
title_fullStr Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress
title_full_unstemmed Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress
title_short Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress
title_sort mitochondrial reactive oxygen species and their contribution in chronic kidney disease progression through oxidative stress
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103168/
https://www.ncbi.nlm.nih.gov/pubmed/33967820
http://dx.doi.org/10.3389/fphys.2021.627837
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