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Evaluation of the Swallow-Tail Sign and Correlations of Neuromelanin Signal with Susceptibility and Relaxations

The presence of a swallow-tail sign in the nigrosome-1 with hyperintense signal shown on the susceptibility-weighted imaging (SWI) has been shown to be sensitive in detecting the abnormal iron deposits in this area. A systematic evaluation in healthy subjects is required before this tool can be reco...

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Autores principales: Lee, Tzu-Wei, Chen, Cheng-Yu, Chen, Kuan, Tso, Chao-Wei, Lin, Hui-Hsien, Lai, Ying-Liang Larry, Hsu, Fei-Ting, Chung, Hsiao-Wen, Liu, Hua-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103261/
https://www.ncbi.nlm.nih.gov/pubmed/33801685
http://dx.doi.org/10.3390/tomography7020010
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author Lee, Tzu-Wei
Chen, Cheng-Yu
Chen, Kuan
Tso, Chao-Wei
Lin, Hui-Hsien
Lai, Ying-Liang Larry
Hsu, Fei-Ting
Chung, Hsiao-Wen
Liu, Hua-Shan
author_facet Lee, Tzu-Wei
Chen, Cheng-Yu
Chen, Kuan
Tso, Chao-Wei
Lin, Hui-Hsien
Lai, Ying-Liang Larry
Hsu, Fei-Ting
Chung, Hsiao-Wen
Liu, Hua-Shan
author_sort Lee, Tzu-Wei
collection PubMed
description The presence of a swallow-tail sign in the nigrosome-1 with hyperintense signal shown on the susceptibility-weighted imaging (SWI) has been shown to be sensitive in detecting the abnormal iron deposits in this area. A systematic evaluation in healthy subjects is required before this tool can be recommended in a widespread application. We evaluated a simple and practical SWI approach using a multiecho gradient-echo sequence with an improved contrast-to-noise ratio (CNR). We also evaluated the association of the neuromelanin imaging contrast behavior with the susceptibility and relaxation measurements. Twenty-five older and 23 young healthy adults were evaluated. The CNRs of the nigrosome-1 were compared along with method and group. Correlations of the nigrosome-1 neuromelanin signal in the neuromelanin-sensitive imaging with CNRs in the susceptibility, T1 and T2 mappings were examined. Two different coils were used to confirm the reproducibility. Compared with the single-echo, multiecho SWI can improve the CNR of the swallow-tail sign. We found significant correlations between neuromelanin signal and CNRs in the susceptibility and T2 mappings, and T1 value. The older subjects exhibited increased CNRs compared with the young adults. No significant difference was observed in the measurements between 20 and 64 channels. The multiecho technique allows the high-quality nigrosome-1 images in SWI and allows for a joint analysis of T2* and quantitative-susceptibility mapping at high spatial resolution. The correlations of neuromelanin-sensitive imaging with susceptibility and T2 imply that the iron content in the nigrosome-1 may have significant influences on the hyperintensity of neuromelanin in the magnetization transfer-related contrast.
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spelling pubmed-81032612021-05-08 Evaluation of the Swallow-Tail Sign and Correlations of Neuromelanin Signal with Susceptibility and Relaxations Lee, Tzu-Wei Chen, Cheng-Yu Chen, Kuan Tso, Chao-Wei Lin, Hui-Hsien Lai, Ying-Liang Larry Hsu, Fei-Ting Chung, Hsiao-Wen Liu, Hua-Shan Tomography Article The presence of a swallow-tail sign in the nigrosome-1 with hyperintense signal shown on the susceptibility-weighted imaging (SWI) has been shown to be sensitive in detecting the abnormal iron deposits in this area. A systematic evaluation in healthy subjects is required before this tool can be recommended in a widespread application. We evaluated a simple and practical SWI approach using a multiecho gradient-echo sequence with an improved contrast-to-noise ratio (CNR). We also evaluated the association of the neuromelanin imaging contrast behavior with the susceptibility and relaxation measurements. Twenty-five older and 23 young healthy adults were evaluated. The CNRs of the nigrosome-1 were compared along with method and group. Correlations of the nigrosome-1 neuromelanin signal in the neuromelanin-sensitive imaging with CNRs in the susceptibility, T1 and T2 mappings were examined. Two different coils were used to confirm the reproducibility. Compared with the single-echo, multiecho SWI can improve the CNR of the swallow-tail sign. We found significant correlations between neuromelanin signal and CNRs in the susceptibility and T2 mappings, and T1 value. The older subjects exhibited increased CNRs compared with the young adults. No significant difference was observed in the measurements between 20 and 64 channels. The multiecho technique allows the high-quality nigrosome-1 images in SWI and allows for a joint analysis of T2* and quantitative-susceptibility mapping at high spatial resolution. The correlations of neuromelanin-sensitive imaging with susceptibility and T2 imply that the iron content in the nigrosome-1 may have significant influences on the hyperintensity of neuromelanin in the magnetization transfer-related contrast. MDPI 2021-03-27 /pmc/articles/PMC8103261/ /pubmed/33801685 http://dx.doi.org/10.3390/tomography7020010 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Lee, Tzu-Wei
Chen, Cheng-Yu
Chen, Kuan
Tso, Chao-Wei
Lin, Hui-Hsien
Lai, Ying-Liang Larry
Hsu, Fei-Ting
Chung, Hsiao-Wen
Liu, Hua-Shan
Evaluation of the Swallow-Tail Sign and Correlations of Neuromelanin Signal with Susceptibility and Relaxations
title Evaluation of the Swallow-Tail Sign and Correlations of Neuromelanin Signal with Susceptibility and Relaxations
title_full Evaluation of the Swallow-Tail Sign and Correlations of Neuromelanin Signal with Susceptibility and Relaxations
title_fullStr Evaluation of the Swallow-Tail Sign and Correlations of Neuromelanin Signal with Susceptibility and Relaxations
title_full_unstemmed Evaluation of the Swallow-Tail Sign and Correlations of Neuromelanin Signal with Susceptibility and Relaxations
title_short Evaluation of the Swallow-Tail Sign and Correlations of Neuromelanin Signal with Susceptibility and Relaxations
title_sort evaluation of the swallow-tail sign and correlations of neuromelanin signal with susceptibility and relaxations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103261/
https://www.ncbi.nlm.nih.gov/pubmed/33801685
http://dx.doi.org/10.3390/tomography7020010
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