Cargando…

Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women

This systematic review evaluates the efficacy and safety of l-arginine alone or in combination for the treatment of women with hypoactive sexual desire disorder (HSDD) or related conditions, such as female sexual interest/arousal disorder and female sexual arousal disorder. Medline, Embase, Internat...

Descripción completa

Detalles Bibliográficos
Autores principales: Cieri-Hutcherson, Nicole E., Jaenecke, Andrea, Bahia, Ajeet, Lucas, Debra, Oluloro, Ann, Stimmel, Lora, Hutcherson, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103282/
https://www.ncbi.nlm.nih.gov/pubmed/33801678
http://dx.doi.org/10.3390/pharmacy9020071
_version_ 1783689288944189440
author Cieri-Hutcherson, Nicole E.
Jaenecke, Andrea
Bahia, Ajeet
Lucas, Debra
Oluloro, Ann
Stimmel, Lora
Hutcherson, Timothy C.
author_facet Cieri-Hutcherson, Nicole E.
Jaenecke, Andrea
Bahia, Ajeet
Lucas, Debra
Oluloro, Ann
Stimmel, Lora
Hutcherson, Timothy C.
author_sort Cieri-Hutcherson, Nicole E.
collection PubMed
description This systematic review evaluates the efficacy and safety of l-arginine alone or in combination for the treatment of women with hypoactive sexual desire disorder (HSDD) or related conditions, such as female sexual interest/arousal disorder and female sexual arousal disorder. Medline, Embase, International Pharmaceutical Abstracts, Science Direct, and the Cumulative Index to Nursing and Allied Health Literature were searched using keywords “arginine”, “Lady Prelox”, “ArginMax”, “Stronvivo”, “Ristela”, “hypoactive sexual desire disorder”, “female sexual interest arousal disorder”, “female sexual arousal disorder”, “sexual dysfunction”, “sexual behavior”, “dyspareunia”, “libido”, and permutations thereof. Relevant records were retained if they were primary literature, conducted in women with HSDD or related conditions, and published as full text in English. Five randomized controlled trials and two nonrandomized studies met eligibility criteria. Six of the seven studies reported either an increase in the total mean Female Sexual Function Index score or significant increases in multiple domains therein. One study assessed vaginal pulse amplitude and found a statistically significant increase in a combination treatment group compared to placebo. No significant side effects were reported. Four of seven studies had potential risk-of-bias concerns per Cochrane assessments. This systematic review found that combination products containing l-arginine in the form of ArginMax or Lady Prelox may be considered for the treatment of HSDD and related conditions in women regardless of age.
format Online
Article
Text
id pubmed-8103282
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81032822021-05-08 Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women Cieri-Hutcherson, Nicole E. Jaenecke, Andrea Bahia, Ajeet Lucas, Debra Oluloro, Ann Stimmel, Lora Hutcherson, Timothy C. Pharmacy (Basel) Systematic Review This systematic review evaluates the efficacy and safety of l-arginine alone or in combination for the treatment of women with hypoactive sexual desire disorder (HSDD) or related conditions, such as female sexual interest/arousal disorder and female sexual arousal disorder. Medline, Embase, International Pharmaceutical Abstracts, Science Direct, and the Cumulative Index to Nursing and Allied Health Literature were searched using keywords “arginine”, “Lady Prelox”, “ArginMax”, “Stronvivo”, “Ristela”, “hypoactive sexual desire disorder”, “female sexual interest arousal disorder”, “female sexual arousal disorder”, “sexual dysfunction”, “sexual behavior”, “dyspareunia”, “libido”, and permutations thereof. Relevant records were retained if they were primary literature, conducted in women with HSDD or related conditions, and published as full text in English. Five randomized controlled trials and two nonrandomized studies met eligibility criteria. Six of the seven studies reported either an increase in the total mean Female Sexual Function Index score or significant increases in multiple domains therein. One study assessed vaginal pulse amplitude and found a statistically significant increase in a combination treatment group compared to placebo. No significant side effects were reported. Four of seven studies had potential risk-of-bias concerns per Cochrane assessments. This systematic review found that combination products containing l-arginine in the form of ArginMax or Lady Prelox may be considered for the treatment of HSDD and related conditions in women regardless of age. MDPI 2021-03-27 /pmc/articles/PMC8103282/ /pubmed/33801678 http://dx.doi.org/10.3390/pharmacy9020071 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Systematic Review
Cieri-Hutcherson, Nicole E.
Jaenecke, Andrea
Bahia, Ajeet
Lucas, Debra
Oluloro, Ann
Stimmel, Lora
Hutcherson, Timothy C.
Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women
title Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women
title_full Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women
title_fullStr Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women
title_full_unstemmed Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women
title_short Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women
title_sort systematic review of l-arginine for the treatment of hypoactive sexual desire disorder and related conditions in women
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103282/
https://www.ncbi.nlm.nih.gov/pubmed/33801678
http://dx.doi.org/10.3390/pharmacy9020071
work_keys_str_mv AT cierihutchersonnicolee systematicreviewoflarginineforthetreatmentofhypoactivesexualdesiredisorderandrelatedconditionsinwomen
AT jaeneckeandrea systematicreviewoflarginineforthetreatmentofhypoactivesexualdesiredisorderandrelatedconditionsinwomen
AT bahiaajeet systematicreviewoflarginineforthetreatmentofhypoactivesexualdesiredisorderandrelatedconditionsinwomen
AT lucasdebra systematicreviewoflarginineforthetreatmentofhypoactivesexualdesiredisorderandrelatedconditionsinwomen
AT oluloroann systematicreviewoflarginineforthetreatmentofhypoactivesexualdesiredisorderandrelatedconditionsinwomen
AT stimmellora systematicreviewoflarginineforthetreatmentofhypoactivesexualdesiredisorderandrelatedconditionsinwomen
AT hutchersontimothyc systematicreviewoflarginineforthetreatmentofhypoactivesexualdesiredisorderandrelatedconditionsinwomen