The dynamic instability of actin filament barbed ends

The turnover of actin filament networks in cells has long been considered to reflect the treadmilling behavior of pure actin filaments in vitro, where only the pointed ends depolymerize. Newly discovered molecular mechanisms challenge this notion, as they provide evidence of situations in which grow...

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Detalles Bibliográficos
Autores principales: Romet-Lemonne, Guillaume, Jégou, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103424/
https://www.ncbi.nlm.nih.gov/pubmed/33755041
http://dx.doi.org/10.1083/jcb.202102020
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author Romet-Lemonne, Guillaume
Jégou, Antoine
author_facet Romet-Lemonne, Guillaume
Jégou, Antoine
author_sort Romet-Lemonne, Guillaume
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description The turnover of actin filament networks in cells has long been considered to reflect the treadmilling behavior of pure actin filaments in vitro, where only the pointed ends depolymerize. Newly discovered molecular mechanisms challenge this notion, as they provide evidence of situations in which growing and depolymerizing barbed ends coexist.
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spelling pubmed-81034242021-10-05 The dynamic instability of actin filament barbed ends Romet-Lemonne, Guillaume Jégou, Antoine J Cell Biol Viewpoint The turnover of actin filament networks in cells has long been considered to reflect the treadmilling behavior of pure actin filaments in vitro, where only the pointed ends depolymerize. Newly discovered molecular mechanisms challenge this notion, as they provide evidence of situations in which growing and depolymerizing barbed ends coexist. Rockefeller University Press 2021-03-23 /pmc/articles/PMC8103424/ /pubmed/33755041 http://dx.doi.org/10.1083/jcb.202102020 Text en © 2021 Romet-Lemonne and Jégou http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Viewpoint
Romet-Lemonne, Guillaume
Jégou, Antoine
The dynamic instability of actin filament barbed ends
title The dynamic instability of actin filament barbed ends
title_full The dynamic instability of actin filament barbed ends
title_fullStr The dynamic instability of actin filament barbed ends
title_full_unstemmed The dynamic instability of actin filament barbed ends
title_short The dynamic instability of actin filament barbed ends
title_sort dynamic instability of actin filament barbed ends
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103424/
https://www.ncbi.nlm.nih.gov/pubmed/33755041
http://dx.doi.org/10.1083/jcb.202102020
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