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Five-Year Follow-Up on the Prevalence and Intensity of Infections of Schistosoma mansoni in a Hard-to-Reach District of Madagascar
Schistosomiasis is a major public health problem in Madagascar. The WHO recommends preventive chemotherapy by mass drug administration (MDA) with praziquantel as the primary approach to control Schistosoma mansoni–related morbidity in endemic populations, alongside complementary interventions such a...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The American Society of Tropical Medicine and Hygiene
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103437/ https://www.ncbi.nlm.nih.gov/pubmed/33684064 http://dx.doi.org/10.4269/ajtmh.20-1433 |
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author | Spencer, Stephen A. Linder, Cortland Penney, James M. StJ. Russell, Hannah J. Hyde, Kate Sheehy, Caitlin Reid, Alice Andriamasy, Emmanuel H. Raderalazasoa, Gina U. Rakotomampianina, Daniel A. L. Nandimbiniaina, Anjara M. Ranaivoson, Tahiry N. Andrianiaina, Antsa Cruickshank, Sheena M. Bustinduy, Amaya L. Stothard, J. Russell Edosoa, Glenn T. Rahetilahy, Alain M. |
author_facet | Spencer, Stephen A. Linder, Cortland Penney, James M. StJ. Russell, Hannah J. Hyde, Kate Sheehy, Caitlin Reid, Alice Andriamasy, Emmanuel H. Raderalazasoa, Gina U. Rakotomampianina, Daniel A. L. Nandimbiniaina, Anjara M. Ranaivoson, Tahiry N. Andrianiaina, Antsa Cruickshank, Sheena M. Bustinduy, Amaya L. Stothard, J. Russell Edosoa, Glenn T. Rahetilahy, Alain M. |
author_sort | Spencer, Stephen A. |
collection | PubMed |
description | Schistosomiasis is a major public health problem in Madagascar. The WHO recommends preventive chemotherapy by mass drug administration (MDA) with praziquantel as the primary approach to control Schistosoma mansoni–related morbidity in endemic populations, alongside complementary interventions such as health education. The impact of annual MDA and health education programs was assessed in the hard-to-reach Marolambo district of eastern Madagascar, an area endemic for S. mansoni. Repeated cross-sectional studies undertaken 2015–2019 examined between 300 and 381 school-aged children (aged 5–14 years) annually. The prevalence and infection intensity of S. mansoni were assessed by urine-circulating cathodic antigen (CCA) dipsticks and coproscopy using Kato–Katz (KK) methodologies. After four rounds of annual MDA, a reduction in S. mansoni prevalence was seen in CCA (93.9% in year 1–87.7% in year 5; P = 0.007) and KK (73.9% in year 1–59.4% in year 5; P < 0.0001). The prevalence of heavy-intensity infections roughly halved from 23.7% to 10.1% (P < 0.0001), and the mean intensity of infection fell by 55.0% (480.2–216.3 eggs per gram of feces). A malacological survey found Biomphalaria pfeifferi snail intermediate hosts in multiple water contact sites including rice paddies, streams, and Nosivolo River. Despite reductions in infection prevalence and intensity, schistosomiasis still poses a significant public health challenge in Marolambo district. Twice yearly MDA cycles and/or community-wide MDA are suggested to better reduce infections. Expanding health education, improving standards of water, sanitation and hygiene, and attention on snail-related control will also be important, especially in rice paddy irrigated areas. |
format | Online Article Text |
id | pubmed-8103437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-81034372021-05-10 Five-Year Follow-Up on the Prevalence and Intensity of Infections of Schistosoma mansoni in a Hard-to-Reach District of Madagascar Spencer, Stephen A. Linder, Cortland Penney, James M. StJ. Russell, Hannah J. Hyde, Kate Sheehy, Caitlin Reid, Alice Andriamasy, Emmanuel H. Raderalazasoa, Gina U. Rakotomampianina, Daniel A. L. Nandimbiniaina, Anjara M. Ranaivoson, Tahiry N. Andrianiaina, Antsa Cruickshank, Sheena M. Bustinduy, Amaya L. Stothard, J. Russell Edosoa, Glenn T. Rahetilahy, Alain M. Am J Trop Med Hyg Articles Schistosomiasis is a major public health problem in Madagascar. The WHO recommends preventive chemotherapy by mass drug administration (MDA) with praziquantel as the primary approach to control Schistosoma mansoni–related morbidity in endemic populations, alongside complementary interventions such as health education. The impact of annual MDA and health education programs was assessed in the hard-to-reach Marolambo district of eastern Madagascar, an area endemic for S. mansoni. Repeated cross-sectional studies undertaken 2015–2019 examined between 300 and 381 school-aged children (aged 5–14 years) annually. The prevalence and infection intensity of S. mansoni were assessed by urine-circulating cathodic antigen (CCA) dipsticks and coproscopy using Kato–Katz (KK) methodologies. After four rounds of annual MDA, a reduction in S. mansoni prevalence was seen in CCA (93.9% in year 1–87.7% in year 5; P = 0.007) and KK (73.9% in year 1–59.4% in year 5; P < 0.0001). The prevalence of heavy-intensity infections roughly halved from 23.7% to 10.1% (P < 0.0001), and the mean intensity of infection fell by 55.0% (480.2–216.3 eggs per gram of feces). A malacological survey found Biomphalaria pfeifferi snail intermediate hosts in multiple water contact sites including rice paddies, streams, and Nosivolo River. Despite reductions in infection prevalence and intensity, schistosomiasis still poses a significant public health challenge in Marolambo district. Twice yearly MDA cycles and/or community-wide MDA are suggested to better reduce infections. Expanding health education, improving standards of water, sanitation and hygiene, and attention on snail-related control will also be important, especially in rice paddy irrigated areas. The American Society of Tropical Medicine and Hygiene 2021-05 2021-03-08 /pmc/articles/PMC8103437/ /pubmed/33684064 http://dx.doi.org/10.4269/ajtmh.20-1433 Text en © The American Society of Tropical Medicine and Hygiene https://creativecommons.org/licenses/by-nc/4.0/Open Access statement. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated. |
spellingShingle | Articles Spencer, Stephen A. Linder, Cortland Penney, James M. StJ. Russell, Hannah J. Hyde, Kate Sheehy, Caitlin Reid, Alice Andriamasy, Emmanuel H. Raderalazasoa, Gina U. Rakotomampianina, Daniel A. L. Nandimbiniaina, Anjara M. Ranaivoson, Tahiry N. Andrianiaina, Antsa Cruickshank, Sheena M. Bustinduy, Amaya L. Stothard, J. Russell Edosoa, Glenn T. Rahetilahy, Alain M. Five-Year Follow-Up on the Prevalence and Intensity of Infections of Schistosoma mansoni in a Hard-to-Reach District of Madagascar |
title | Five-Year Follow-Up on the Prevalence and Intensity of Infections of Schistosoma mansoni in a Hard-to-Reach District of Madagascar |
title_full | Five-Year Follow-Up on the Prevalence and Intensity of Infections of Schistosoma mansoni in a Hard-to-Reach District of Madagascar |
title_fullStr | Five-Year Follow-Up on the Prevalence and Intensity of Infections of Schistosoma mansoni in a Hard-to-Reach District of Madagascar |
title_full_unstemmed | Five-Year Follow-Up on the Prevalence and Intensity of Infections of Schistosoma mansoni in a Hard-to-Reach District of Madagascar |
title_short | Five-Year Follow-Up on the Prevalence and Intensity of Infections of Schistosoma mansoni in a Hard-to-Reach District of Madagascar |
title_sort | five-year follow-up on the prevalence and intensity of infections of schistosoma mansoni in a hard-to-reach district of madagascar |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103437/ https://www.ncbi.nlm.nih.gov/pubmed/33684064 http://dx.doi.org/10.4269/ajtmh.20-1433 |
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