Cargando…

Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant

OBJECTIVE: This study aims to describe presenting characteristics of patients diagnosed with non-invasive chronic rhinosinusitis (CRS) following liver or kidney transplant and determine factors associated with disease-related complications, selection of endoscopic sinus surgery (ESS), and disease re...

Descripción completa

Detalles Bibliográficos
Autores principales: Spillinger, Aviv, Low, Christopher M., Smith, Byron M., Stokken, Janalee K., O'Brien, Erin K., Choby, Garret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103524/
https://www.ncbi.nlm.nih.gov/pubmed/33997724
http://dx.doi.org/10.1016/j.wjorl.2020.05.001
_version_ 1783689324281200640
author Spillinger, Aviv
Low, Christopher M.
Smith, Byron M.
Stokken, Janalee K.
O'Brien, Erin K.
Choby, Garret
author_facet Spillinger, Aviv
Low, Christopher M.
Smith, Byron M.
Stokken, Janalee K.
O'Brien, Erin K.
Choby, Garret
author_sort Spillinger, Aviv
collection PubMed
description OBJECTIVE: This study aims to describe presenting characteristics of patients diagnosed with non-invasive chronic rhinosinusitis (CRS) following liver or kidney transplant and determine factors associated with disease-related complications, selection of endoscopic sinus surgery (ESS), and disease resolution in this population. STUDY DESIGN: Retrospective chart review. SETTING: An academic tertiary care center (Mayo Clinic, Rochester, Minnesota). SUBJECTS AND METHODS: Liver and kidney transplant recipients evaluated by Mayo Clinic otolaryngologists for CRS between 1998 and 2018 were identified. Univariate and multivariate logistic regression analyses were used to determine patient factors and treatment modalities associated with developing complications, selection of ESS, and disease resolution. RESULTS: Fifty-seven patients met inclusion criteria. No patients developed intraorbital or intracranial complications of their CRS. Multivariate modeling demonstrated that the presence of polyps (P = 0.036) was associated with undergoing ESS within one year of presentation. A higher Lund–Mackay (LM) computed tomography score (P = 0.023) and older age (P = 0.018) were significantly associated with decreased disease resolution. No other factors were significantly associated with the use of endoscopic sinus surgery within one year of otolaryngology presentation or resolution of CRS in this cohort. CONCLUSION: The risk of developing CRS-related intraorbital or intracranial complications in this immunecompromised patient cohort may be lower than originally thought. For liver- and kidney-recipients stable on immunosuppressive medication for many years, prognostic factors for CRS may mirror those for immunocompetent patients.
format Online
Article
Text
id pubmed-8103524
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher KeAi Publishing
record_format MEDLINE/PubMed
spelling pubmed-81035242021-05-13 Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant Spillinger, Aviv Low, Christopher M. Smith, Byron M. Stokken, Janalee K. O'Brien, Erin K. Choby, Garret World J Otorhinolaryngol Head Neck Surg Research Paper OBJECTIVE: This study aims to describe presenting characteristics of patients diagnosed with non-invasive chronic rhinosinusitis (CRS) following liver or kidney transplant and determine factors associated with disease-related complications, selection of endoscopic sinus surgery (ESS), and disease resolution in this population. STUDY DESIGN: Retrospective chart review. SETTING: An academic tertiary care center (Mayo Clinic, Rochester, Minnesota). SUBJECTS AND METHODS: Liver and kidney transplant recipients evaluated by Mayo Clinic otolaryngologists for CRS between 1998 and 2018 were identified. Univariate and multivariate logistic regression analyses were used to determine patient factors and treatment modalities associated with developing complications, selection of ESS, and disease resolution. RESULTS: Fifty-seven patients met inclusion criteria. No patients developed intraorbital or intracranial complications of their CRS. Multivariate modeling demonstrated that the presence of polyps (P = 0.036) was associated with undergoing ESS within one year of presentation. A higher Lund–Mackay (LM) computed tomography score (P = 0.023) and older age (P = 0.018) were significantly associated with decreased disease resolution. No other factors were significantly associated with the use of endoscopic sinus surgery within one year of otolaryngology presentation or resolution of CRS in this cohort. CONCLUSION: The risk of developing CRS-related intraorbital or intracranial complications in this immunecompromised patient cohort may be lower than originally thought. For liver- and kidney-recipients stable on immunosuppressive medication for many years, prognostic factors for CRS may mirror those for immunocompetent patients. KeAi Publishing 2020-06-04 /pmc/articles/PMC8103524/ /pubmed/33997724 http://dx.doi.org/10.1016/j.wjorl.2020.05.001 Text en © 2020 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Spillinger, Aviv
Low, Christopher M.
Smith, Byron M.
Stokken, Janalee K.
O'Brien, Erin K.
Choby, Garret
Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title_full Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title_fullStr Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title_full_unstemmed Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title_short Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title_sort presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103524/
https://www.ncbi.nlm.nih.gov/pubmed/33997724
http://dx.doi.org/10.1016/j.wjorl.2020.05.001
work_keys_str_mv AT spillingeraviv presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant
AT lowchristopherm presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant
AT smithbyronm presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant
AT stokkenjanaleek presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant
AT obrienerink presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant
AT chobygarret presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant