Promoter G-quadruplex folding precedes transcription and is controlled by chromatin

BACKGROUND: Four-stranded G-quadruplexes (G4s) are DNA secondary structures in the human genome that are primarily found in active promoters associated with elevated transcription. Here, we explore the relationship between the folding of promoter G4s, transcription and chromatin state. RESULTS: Tran...

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Detalles Bibliográficos
Autores principales: Shen, Jiazhen, Varshney, Dhaval, Simeone, Angela, Zhang, Xiaoyun, Adhikari, Santosh, Tannahill, David, Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103603/
https://www.ncbi.nlm.nih.gov/pubmed/33962653
http://dx.doi.org/10.1186/s13059-021-02346-7

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