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The effects of secondary iron overload and iron chelation on a radiation-induced acute myeloid leukemia mouse model

BACKGROUND: Patients with myelodysplastic syndrome (MDS) require chronic red blood cell (RBC) transfusion due to anemia. Multiple RBC transfusions cause secondary iron overload and subsequent excessive generation of reactive oxygen species (ROS), which leads to mutations, cell death, organ failure,...

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Detalles Bibliográficos
Autores principales:	Chan, Lap Shu Alan, Gu, Lilly ChunHong, Wells, Richard A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103632/ https://www.ncbi.nlm.nih.gov/pubmed/33957868 http://dx.doi.org/10.1186/s12885-021-08259-9

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