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hERG-deficient human embryonic stem cell-derived cardiomyocytes for modelling QT prolongation

BACKGROUND: Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclear. In this study, we generated an hERG-deficient human car...

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Detalles Bibliográficos
Autores principales:	Chang, Yun, Li, Ya-nan, Bai, Rui, Wu, Fujian, Ma, Shuhong, Saleem, Amina, Zhang, Siyao, Jiang, Youxu, Dong, Tao, Guo, Tianwei, Hang, Chengwen, Lu, Wen-jing, Jiang, Hongfeng, Lan, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103639/ https://www.ncbi.nlm.nih.gov/pubmed/33962658 http://dx.doi.org/10.1186/s13287-021-02346-1

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