A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker

BACKGROUND: Disulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of copper when administered with disulfiram in patients with advanced solid tumors and liver involvement. METHODS: Disulfiram 250 mg...

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Detalles Bibliográficos
Autores principales: Kelley, Kristen C., Grossman, Kenneth F., Brittain-Blankenship, Mary, Thorne, Kelli M., Akerley, Wallace L., Terrazas, Moises C., Kosak, Ken M., Boucher, Kenneth M., Buys, Saundra S., McGregor, Kimberly A., Werner, Theresa L., Agarwal, Neeraj, Weis, John R., Sharma, Sunil, Ward, John H., Kennedy, Thomas P., Sborov, Douglas W., Shami, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103752/
https://www.ncbi.nlm.nih.gov/pubmed/33957901
http://dx.doi.org/10.1186/s12885-021-08242-4

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