Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus

Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility of adverse metabolic effects of these medications. We describe 3 cases in which PWH developed hyperglyce...

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Autores principales: Nolan, Nathanial S, Adamson, Samantha, Reeds, Dominic, O’Halloran, Jane A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103800/
https://www.ncbi.nlm.nih.gov/pubmed/33981777
http://dx.doi.org/10.1093/ofid/ofab077
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author Nolan, Nathanial S
Adamson, Samantha
Reeds, Dominic
O’Halloran, Jane A
author_facet Nolan, Nathanial S
Adamson, Samantha
Reeds, Dominic
O’Halloran, Jane A
author_sort Nolan, Nathanial S
collection PubMed
description Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility of adverse metabolic effects of these medications. We describe 3 cases in which PWH developed hyperglycemia and ketoacidosis within months of being switched to bictegravir-based ART.
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spelling pubmed-81038002021-05-11 Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus Nolan, Nathanial S Adamson, Samantha Reeds, Dominic O’Halloran, Jane A Open Forum Infect Dis Brief Reports Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility of adverse metabolic effects of these medications. We describe 3 cases in which PWH developed hyperglycemia and ketoacidosis within months of being switched to bictegravir-based ART. Oxford University Press 2021-04-16 /pmc/articles/PMC8103800/ /pubmed/33981777 http://dx.doi.org/10.1093/ofid/ofab077 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Nolan, Nathanial S
Adamson, Samantha
Reeds, Dominic
O’Halloran, Jane A
Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus
title Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus
title_full Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus
title_fullStr Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus
title_full_unstemmed Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus
title_short Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus
title_sort bictegravir-based antiretroviral therapy-associated accelerated hyperglycemia and diabetes mellitus
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103800/
https://www.ncbi.nlm.nih.gov/pubmed/33981777
http://dx.doi.org/10.1093/ofid/ofab077
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