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Adipotropic effects of heavy metals and their potential role in obesity

Epidemiological studies demonstrated an association between heavy metal exposure and the incidence of obesity and metabolic syndrome. However, the particular effects of metal toxicity on adipose tissue functioning are unclear. Therefore, recent findings of direct influence of heavy metals (mercury,...

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Autores principales: Tinkov, Alexey A, Aschner, Michael, Ke, Tao, Ferrer, Beatriz, Zhou, Ji-Chang, Chang, Jung-Su, Santamaría, Abel, Chao, Jane C.-J., Aaseth, Jan, Skalny, Anatoly V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty Opinions Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103910/
https://www.ncbi.nlm.nih.gov/pubmed/33977285
http://dx.doi.org/10.12703/r/10-32
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author Tinkov, Alexey A
Aschner, Michael
Ke, Tao
Ferrer, Beatriz
Zhou, Ji-Chang
Chang, Jung-Su
Santamaría, Abel
Chao, Jane C.-J.
Aaseth, Jan
Skalny, Anatoly V
author_facet Tinkov, Alexey A
Aschner, Michael
Ke, Tao
Ferrer, Beatriz
Zhou, Ji-Chang
Chang, Jung-Su
Santamaría, Abel
Chao, Jane C.-J.
Aaseth, Jan
Skalny, Anatoly V
author_sort Tinkov, Alexey A
collection PubMed
description Epidemiological studies demonstrated an association between heavy metal exposure and the incidence of obesity and metabolic syndrome. However, the particular effects of metal toxicity on adipose tissue functioning are unclear. Therefore, recent findings of direct influence of heavy metals (mercury, cadmium, and lead) and metalloid (arsenic) on adipose tissue physiology are discussed while considering existing gaps and contradictions. Here, we provide a literature review addressing adipose tissue as a potential target of heavy metal toxicity. Experimental in vivo studies demonstrated a significant influence of mercury, cadmium, lead, and arsenic exposure on body adiposity. In turn, in vitro experiments revealed both up- and downregulation of adipogenesis associated with aberrant expression of key adipogenic pathways, namely CCAAT/enhancer-binding protein (C/EBP) and peroxisome proliferator-activated receptor gamma (PPARγ). Comparison of the existing studies on the basis of dose and route of exposure demonstrated that the effects of heavy metal exposure on adipose tissue may be dose-dependent, varying from increased adipogenesis at low-dose exposure to inhibition of adipose tissue differentiation at higher doses. However, direct dose-response data are available in a single study only for arsenic. Nonetheless, both types of these effects, irrespective of their directionality, contribute significantly to metabolic disturbances due to dysregulated adipogenesis. Particularly, inhibition of adipocyte differentiation is known to reduce lipid-storage capacity of adipose tissue, leading to ectopic lipid accumulation. In contrast, metal-associated stimulation of adipogenesis may result in increased adipose tissue accumulation and obesity. However, further studies are required to reveal the particular dose- and species-dependent effects of heavy metal exposure on adipogenesis and adipose tissue functioning.
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spelling pubmed-81039102021-05-10 Adipotropic effects of heavy metals and their potential role in obesity Tinkov, Alexey A Aschner, Michael Ke, Tao Ferrer, Beatriz Zhou, Ji-Chang Chang, Jung-Su Santamaría, Abel Chao, Jane C.-J. Aaseth, Jan Skalny, Anatoly V Fac Rev Review Article Epidemiological studies demonstrated an association between heavy metal exposure and the incidence of obesity and metabolic syndrome. However, the particular effects of metal toxicity on adipose tissue functioning are unclear. Therefore, recent findings of direct influence of heavy metals (mercury, cadmium, and lead) and metalloid (arsenic) on adipose tissue physiology are discussed while considering existing gaps and contradictions. Here, we provide a literature review addressing adipose tissue as a potential target of heavy metal toxicity. Experimental in vivo studies demonstrated a significant influence of mercury, cadmium, lead, and arsenic exposure on body adiposity. In turn, in vitro experiments revealed both up- and downregulation of adipogenesis associated with aberrant expression of key adipogenic pathways, namely CCAAT/enhancer-binding protein (C/EBP) and peroxisome proliferator-activated receptor gamma (PPARγ). Comparison of the existing studies on the basis of dose and route of exposure demonstrated that the effects of heavy metal exposure on adipose tissue may be dose-dependent, varying from increased adipogenesis at low-dose exposure to inhibition of adipose tissue differentiation at higher doses. However, direct dose-response data are available in a single study only for arsenic. Nonetheless, both types of these effects, irrespective of their directionality, contribute significantly to metabolic disturbances due to dysregulated adipogenesis. Particularly, inhibition of adipocyte differentiation is known to reduce lipid-storage capacity of adipose tissue, leading to ectopic lipid accumulation. In contrast, metal-associated stimulation of adipogenesis may result in increased adipose tissue accumulation and obesity. However, further studies are required to reveal the particular dose- and species-dependent effects of heavy metal exposure on adipogenesis and adipose tissue functioning. Faculty Opinions Ltd 2021-03-26 /pmc/articles/PMC8103910/ /pubmed/33977285 http://dx.doi.org/10.12703/r/10-32 Text en Copyright: © 2021 Aschner M et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tinkov, Alexey A
Aschner, Michael
Ke, Tao
Ferrer, Beatriz
Zhou, Ji-Chang
Chang, Jung-Su
Santamaría, Abel
Chao, Jane C.-J.
Aaseth, Jan
Skalny, Anatoly V
Adipotropic effects of heavy metals and their potential role in obesity
title Adipotropic effects of heavy metals and their potential role in obesity
title_full Adipotropic effects of heavy metals and their potential role in obesity
title_fullStr Adipotropic effects of heavy metals and their potential role in obesity
title_full_unstemmed Adipotropic effects of heavy metals and their potential role in obesity
title_short Adipotropic effects of heavy metals and their potential role in obesity
title_sort adipotropic effects of heavy metals and their potential role in obesity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103910/
https://www.ncbi.nlm.nih.gov/pubmed/33977285
http://dx.doi.org/10.12703/r/10-32
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