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Hyperbaric oxygen therapy decreases mortality due to Fournier’s gangrene: a retrospective comparative study
There is no consensus about the role of adjunctive hyperbaric oxygen therapy (HBOT) in the management of Fournier’s gangrene. The aim of this study was to compare the evolution of patients with Fournier’s gangrene treated with all classical measures with and without adjuvant HBOT. A retrospective co...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103972/ https://www.ncbi.nlm.nih.gov/pubmed/33642333 http://dx.doi.org/10.4103/2045-9912.310055 |
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author | Féres, Omar Feitosa, Marley Ribeiro da Rocha, José Joaquim Ribeiro Miranda, Juliana Mamede dos Santos, Luciana Egydio Féres, Artur Cury de Camargo, Hugo Parra Parra, Rogério Serafim |
author_facet | Féres, Omar Feitosa, Marley Ribeiro da Rocha, José Joaquim Ribeiro Miranda, Juliana Mamede dos Santos, Luciana Egydio Féres, Artur Cury de Camargo, Hugo Parra Parra, Rogério Serafim |
author_sort | Féres, Omar |
collection | PubMed |
description | There is no consensus about the role of adjunctive hyperbaric oxygen therapy (HBOT) in the management of Fournier’s gangrene. The aim of this study was to compare the evolution of patients with Fournier’s gangrene treated with all classical measures with and without adjuvant HBOT. A retrospective comparative study regarding the evolution of patients treated for Fournier’s gangrene was conducted in two periods. In period I, from 1990 to 2002, patients received standard treatments for Fournier’s gangrene, which consisted of surgical debridement, antibiotic therapy and intensive care. In period II, from 2012 to 2019, adjunctive HBOT was added to the classical management strategy. All patients were assigned into four groups according to the anatomical severity classification and the area affected after the first debridement. This classification ensured that the groups could be comparable. The total number of patients in this study was 197, and these patients were divided into control group (118/59.9%) and HBOT group (79/40.1%). The mean age, comorbidities, and anatomical severity classification were similar between the two groups. In period I, 34 out of 118 (28.8%) patients died, while in the HBOT group, 3 out of 77 (3.7%) patients died (P < 0.001). The use of adjuvant HBOT in combination with classical treatment was associated with reduced mortality. This study was approved by the Institutional Review Board and the Ethics Committee of Ribeirão Preto Medical School, University of São Paulo, Brazil (No. 08/2018) on May 2, 2018. |
format | Online Article Text |
id | pubmed-8103972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-81039722021-06-02 Hyperbaric oxygen therapy decreases mortality due to Fournier’s gangrene: a retrospective comparative study Féres, Omar Feitosa, Marley Ribeiro da Rocha, José Joaquim Ribeiro Miranda, Juliana Mamede dos Santos, Luciana Egydio Féres, Artur Cury de Camargo, Hugo Parra Parra, Rogério Serafim Med Gas Res Research Article There is no consensus about the role of adjunctive hyperbaric oxygen therapy (HBOT) in the management of Fournier’s gangrene. The aim of this study was to compare the evolution of patients with Fournier’s gangrene treated with all classical measures with and without adjuvant HBOT. A retrospective comparative study regarding the evolution of patients treated for Fournier’s gangrene was conducted in two periods. In period I, from 1990 to 2002, patients received standard treatments for Fournier’s gangrene, which consisted of surgical debridement, antibiotic therapy and intensive care. In period II, from 2012 to 2019, adjunctive HBOT was added to the classical management strategy. All patients were assigned into four groups according to the anatomical severity classification and the area affected after the first debridement. This classification ensured that the groups could be comparable. The total number of patients in this study was 197, and these patients were divided into control group (118/59.9%) and HBOT group (79/40.1%). The mean age, comorbidities, and anatomical severity classification were similar between the two groups. In period I, 34 out of 118 (28.8%) patients died, while in the HBOT group, 3 out of 77 (3.7%) patients died (P < 0.001). The use of adjuvant HBOT in combination with classical treatment was associated with reduced mortality. This study was approved by the Institutional Review Board and the Ethics Committee of Ribeirão Preto Medical School, University of São Paulo, Brazil (No. 08/2018) on May 2, 2018. Wolters Kluwer - Medknow 2021-02-26 /pmc/articles/PMC8103972/ /pubmed/33642333 http://dx.doi.org/10.4103/2045-9912.310055 Text en Copyright: © 2021 Medical Gas Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Féres, Omar Feitosa, Marley Ribeiro da Rocha, José Joaquim Ribeiro Miranda, Juliana Mamede dos Santos, Luciana Egydio Féres, Artur Cury de Camargo, Hugo Parra Parra, Rogério Serafim Hyperbaric oxygen therapy decreases mortality due to Fournier’s gangrene: a retrospective comparative study |
title | Hyperbaric oxygen therapy decreases mortality due to Fournier’s gangrene: a retrospective comparative study |
title_full | Hyperbaric oxygen therapy decreases mortality due to Fournier’s gangrene: a retrospective comparative study |
title_fullStr | Hyperbaric oxygen therapy decreases mortality due to Fournier’s gangrene: a retrospective comparative study |
title_full_unstemmed | Hyperbaric oxygen therapy decreases mortality due to Fournier’s gangrene: a retrospective comparative study |
title_short | Hyperbaric oxygen therapy decreases mortality due to Fournier’s gangrene: a retrospective comparative study |
title_sort | hyperbaric oxygen therapy decreases mortality due to fournier’s gangrene: a retrospective comparative study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103972/ https://www.ncbi.nlm.nih.gov/pubmed/33642333 http://dx.doi.org/10.4103/2045-9912.310055 |
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