Cargando…

Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome: Clinical Development of a Calcium Release-Activated Calcium Channel Inhibitor

To assess the safety of Auxora in patients with acute pancreatitis (AP), systemic inflammatory response syndrome (SIRS), and hypoxemia, and identify efficacy endpoints to prospectively test in future studies. METHODS: This phase 2, open-label, dose-response study randomized patients with AP, accompa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bruen, Charles, Miller, Joseph, Wilburn, John, Mackey, Caleb, Bollen, Thomas L., Stauderman, Kenneth, Hebbar, Sudarshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104014/ https://www.ncbi.nlm.nih.gov/pubmed/33939666 http://dx.doi.org/10.1097/MPA.0000000000001793

Ejemplares similares

Auxora versus standard of care for the treatment of severe or critical COVID-19 pneumonia: results from a randomized controlled trial
por: Miller, Joseph, et al.
Publicado: (2020)

Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial
por: Bruen, Charles, et al.
Publicado: (2022)

Orai1 calcium channel inhibition prevents progression of chronic pancreatitis
por: Szabó, Viktória, et al.
Publicado: (2023)

A Store-operated Calcium Channel in Drosophila S2 Cells
por: Yeromin, Andriy V., et al.
Publicado: (2004)

Quantal calcium release and calcium entry in the pancreatic acinar cell.
por: Pandol, S. J., et al.
Publicado: (1992)

Bidirectional regulation of calcium release–activated calcium (CRAC) channel by SARAF
por: Zomot, Elia, et al.
Publicado: (2021)

Cortisol modulates calcium release-activated calcium channel gating in fish hepatocytes
por: Das, Chinmayee, et al.
Publicado: (2021)

Ultrastructure of the calcium release channel of sarcoplasmic reticulum
Publicado: (1988)

Tuberculosis of the Wrist Accompanied with Calcium Pyrophosphate
por: Watanabe, Kenya, et al.
Publicado: (2017)

Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism
por: Petrou, Terry, et al.
Publicado: (2017)

Effect of spatial arrangement of presynaptic calcium channels on the calcium current cooperativity of neurotransmitter release
por: Matveev, Victor, et al.
Publicado: (2011)

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling
por: Dulhunty, Angela F., et al.
Publicado: (2018)

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
por: Hou, Xiaowei, et al.
Publicado: (2020)

Calcium Release-Activated Calcium (CRAC) Channel Inhibition Suppresses Pancreatic Ductal Adenocarcinoma Cell Proliferation and Patient-Derived Tumor Growth
por: Khan, Husain Yar, et al.
Publicado: (2020)

Molecular characterization of the calcium release channel deficiency syndrome
por: Tester, David J., et al.
Publicado: (2020)

Calcium Channel Blocker Overdose Treated with Calcium Resulting in Pancreatitis: A Case Report
por: Khan, Salman, et al.
Publicado: (2019)

T-Time: A data repository of T cell and calcium release-activated calcium channel activation imagery
por: Arbuckle, Cody, et al.
Publicado: (2017)

Calcium‐induced calcium release in proximity to hair cell BK channels revealed by PKA activation
por: Bai, Jun‐ping, et al.
Publicado: (2020)

Overcoming Confounding to Characterize the Effects of Calcium Channel Blockers
por: Rajagopal, Sudarshan, et al.
Publicado: (2023)

Calcium Channels and Calcium-Binding Proteins
por: Mochida, Sumiko
Publicado: (2023)

Investigation of the Accompaniment of Calcium During Active Calcium Transport from Human Erythrocyte Ghosts
por: Olson, Erik J., et al.
Publicado: (1974)

Novel Regulation of Calcium Inhibition of the Inositol 1,4,5-trisphosphate Receptor Calcium-release Channel
por: Mak, Don-On Daniel, et al.
Publicado: (2003)

N-terminus oligomerization is conserved in intracellular calcium release channels
por: Zissimopoulos, Spyros, et al.
Publicado: (2014)

Transient increase in calcium efflux accompanies fertilization in Chlamydomonas
Publicado: (1983)

Calcium-Induced Calcium Release in Smooth Muscle: Loose Coupling between the Action Potential and Calcium Release
por: Collier, M.L., et al.
Publicado: (2000)

Ascorbic acid modulation of calcium channels in pancreatic beta cells
Publicado: (1993)

Calcium channel blockers potentiate gemcitabine chemotherapy in pancreatic cancer
por: Principe, Daniel R., et al.
Publicado: (2022)

Effects of local anesthetics on single channel behavior of skeletal muscle calcium release channel
Publicado: (1993)

Modal Gating of Human Ca(V)2.1 (P/Q-type) Calcium Channels: I. The Slow and the Fast Gating Modes and their Modulation by β Subunits
por: Luvisetto, Siro, et al.
Publicado: (2004)

Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels
por: Maltsev, Alexander V., et al.
Publicado: (2017)

A model of propagating calcium-induced calcium release mediated by calcium diffusion
Publicado: (1989)

Cortical localization of a calcium release channel in sea urchin eggs
Publicado: (1992)

The Involvement of Voltage-Operated Calcium Channels in Somato-Dendritic Oxytocin Release
por: Tobin, Vicky A., et al.
Publicado: (2011)

Hypernitrosylated ryanodine receptor/calcium release channels are leaky in dystrophic muscle
por: Bellinger, Andrew M., et al.
Publicado: (2009)

Suppression of Store-operated Calcium Entry Channels and Cytokine Release by Cannabinoids
por: Kozak, J Ashot
Publicado: (2022)

Calcium channels SMA
por: Williams, Ruth
Publicado: (2007)

Calcium channel roundup
por: Leslie, Mitch
Publicado: (2009)

Calcium channel gating
por: Hering, S., et al.
Publicado: (2018)

Presynaptic Calcium Channels
por: Mochida, Sumiko
Publicado: (2019)

Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer
por: Ibrahim, Sajida, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_37k7rddpolfa62mvd0nmduvhuo