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Pathological Hyperinsulinemia and Hyperglycemia in the Impaired Glucose Tolerance Stage Mediate Endothelial Dysfunction Through miR-21, PTEN/AKT/eNOS, and MARK/ET-1 Pathways

BACKGROUND: Impaired glucose tolerance (IGT) is an important prediabetic stage characterized by elevated concentrations of glucose and insulin in the blood. The pathological hyperglycemia and hyperinsulinemia in IGT may regulate the expression of microRNA-21 (miR-21) and affect the downstream insuli...

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Detalles Bibliográficos
Autores principales:	Liu, Ran, Guan, Shilin, Gao, Zhongai, Wang, Jingyu, Xu, Jie, Hao, Zhaohu, Zhang, Yi, Yang, Shaohua, Guo, Zhenhong, Yang, Juhong, Shao, Hailin, Chang, Baocheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104127/ https://www.ncbi.nlm.nih.gov/pubmed/33967958 http://dx.doi.org/10.3389/fendo.2021.644159

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