Cargando…
Correlation between 25-hydroxyvitamin D level and arterial elasticity in middle-aged and elderly cadres in Guiyang, China: A retrospective observational study
There is evidence that serum 25-hydroxyvitamin D [25-(OH) D] levels may be associated with cardiovascular disease and its risk factors. This study aimed to investigate the relationship between 25-(OH) D levels and blood pressure (BP), blood lipids, and arterial elasticity in middle-aged and elderly...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104250/ https://www.ncbi.nlm.nih.gov/pubmed/33950991 http://dx.doi.org/10.1097/MD.0000000000025826 |
_version_ | 1783689454913847296 |
---|---|
author | Shi, Lan Zhang, Qiao Song, Sai-Nan Ma, Lin Chang, Qing Zhang, Shuang-Yun |
author_facet | Shi, Lan Zhang, Qiao Song, Sai-Nan Ma, Lin Chang, Qing Zhang, Shuang-Yun |
author_sort | Shi, Lan |
collection | PubMed |
description | There is evidence that serum 25-hydroxyvitamin D [25-(OH) D] levels may be associated with cardiovascular disease and its risk factors. This study aimed to investigate the relationship between 25-(OH) D levels and blood pressure (BP), blood lipids, and arterial elasticity in middle-aged and elderly cadres in China. In this retrospective study, we included 401 civil servants and cadres aged >42 years who underwent medical examinations at Guiyang Municipal First People's Hospital, China in 2018. The participants were assigned to deficiency (≤20 ng/mL), insufficiency (20–30 ng/mL), and sufficiency (≥30 ng/mL) groups according to 25-(OH) D levels in their blood. Demographics, brachial–ankle pulse wave velocity (baPWV), BP, ankle–brachial index (ABI), and blood lipids were compared among groups. The associations between 25-(OH) D and other parameters were evaluated using linear regression analysis. Median (range) 25-(OH) D levels in the deficiency (n = 162), insufficiency (n = 162), and sufficiency (n = 77) groups were 15.32 (2.93–19.88), 25.12 (20.07–29.91), and 33.91 (30.23–82.42) ng/mL, respectively. There were significant differences in systolic BP, pulse pressure, baPWV (left and right sides), ABI (left side), high-density lipoprotein-cholesterol, and triglycerides (TGs; all P < .05) among groups. Multivariate linear regression revealed that TG, left baPWV, and right baPWV were significantly negatively correlated with 25-(OH) D levels (all P < .05). In this study, 25-(OH) D levels were found to be associated with TG, left baPWV, and right baPWV values. 25-(OH) D deficiency may be associated with reduced arterial elasticity. |
format | Online Article Text |
id | pubmed-8104250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-81042502021-05-10 Correlation between 25-hydroxyvitamin D level and arterial elasticity in middle-aged and elderly cadres in Guiyang, China: A retrospective observational study Shi, Lan Zhang, Qiao Song, Sai-Nan Ma, Lin Chang, Qing Zhang, Shuang-Yun Medicine (Baltimore) 3400 There is evidence that serum 25-hydroxyvitamin D [25-(OH) D] levels may be associated with cardiovascular disease and its risk factors. This study aimed to investigate the relationship between 25-(OH) D levels and blood pressure (BP), blood lipids, and arterial elasticity in middle-aged and elderly cadres in China. In this retrospective study, we included 401 civil servants and cadres aged >42 years who underwent medical examinations at Guiyang Municipal First People's Hospital, China in 2018. The participants were assigned to deficiency (≤20 ng/mL), insufficiency (20–30 ng/mL), and sufficiency (≥30 ng/mL) groups according to 25-(OH) D levels in their blood. Demographics, brachial–ankle pulse wave velocity (baPWV), BP, ankle–brachial index (ABI), and blood lipids were compared among groups. The associations between 25-(OH) D and other parameters were evaluated using linear regression analysis. Median (range) 25-(OH) D levels in the deficiency (n = 162), insufficiency (n = 162), and sufficiency (n = 77) groups were 15.32 (2.93–19.88), 25.12 (20.07–29.91), and 33.91 (30.23–82.42) ng/mL, respectively. There were significant differences in systolic BP, pulse pressure, baPWV (left and right sides), ABI (left side), high-density lipoprotein-cholesterol, and triglycerides (TGs; all P < .05) among groups. Multivariate linear regression revealed that TG, left baPWV, and right baPWV were significantly negatively correlated with 25-(OH) D levels (all P < .05). In this study, 25-(OH) D levels were found to be associated with TG, left baPWV, and right baPWV values. 25-(OH) D deficiency may be associated with reduced arterial elasticity. Lippincott Williams & Wilkins 2021-05-07 /pmc/articles/PMC8104250/ /pubmed/33950991 http://dx.doi.org/10.1097/MD.0000000000025826 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 3400 Shi, Lan Zhang, Qiao Song, Sai-Nan Ma, Lin Chang, Qing Zhang, Shuang-Yun Correlation between 25-hydroxyvitamin D level and arterial elasticity in middle-aged and elderly cadres in Guiyang, China: A retrospective observational study |
title | Correlation between 25-hydroxyvitamin D level and arterial elasticity in middle-aged and elderly cadres in Guiyang, China: A retrospective observational study |
title_full | Correlation between 25-hydroxyvitamin D level and arterial elasticity in middle-aged and elderly cadres in Guiyang, China: A retrospective observational study |
title_fullStr | Correlation between 25-hydroxyvitamin D level and arterial elasticity in middle-aged and elderly cadres in Guiyang, China: A retrospective observational study |
title_full_unstemmed | Correlation between 25-hydroxyvitamin D level and arterial elasticity in middle-aged and elderly cadres in Guiyang, China: A retrospective observational study |
title_short | Correlation between 25-hydroxyvitamin D level and arterial elasticity in middle-aged and elderly cadres in Guiyang, China: A retrospective observational study |
title_sort | correlation between 25-hydroxyvitamin d level and arterial elasticity in middle-aged and elderly cadres in guiyang, china: a retrospective observational study |
topic | 3400 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104250/ https://www.ncbi.nlm.nih.gov/pubmed/33950991 http://dx.doi.org/10.1097/MD.0000000000025826 |
work_keys_str_mv | AT shilan correlationbetween25hydroxyvitamindlevelandarterialelasticityinmiddleagedandelderlycadresinguiyangchinaaretrospectiveobservationalstudy AT zhangqiao correlationbetween25hydroxyvitamindlevelandarterialelasticityinmiddleagedandelderlycadresinguiyangchinaaretrospectiveobservationalstudy AT songsainan correlationbetween25hydroxyvitamindlevelandarterialelasticityinmiddleagedandelderlycadresinguiyangchinaaretrospectiveobservationalstudy AT malin correlationbetween25hydroxyvitamindlevelandarterialelasticityinmiddleagedandelderlycadresinguiyangchinaaretrospectiveobservationalstudy AT changqing correlationbetween25hydroxyvitamindlevelandarterialelasticityinmiddleagedandelderlycadresinguiyangchinaaretrospectiveobservationalstudy AT zhangshuangyun correlationbetween25hydroxyvitamindlevelandarterialelasticityinmiddleagedandelderlycadresinguiyangchinaaretrospectiveobservationalstudy |