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Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum

Our understanding of folate metabolism in Leishmania has greatly benefited from studies of resistance to the inhibitor methotrexate (MTX). Folates are reduced in Leishmania by the bifunctional dihydrofolate reductase thymidylate synthase (DHFR-TS) and by pteridine reductase (PTR1). To further our un...

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Detalles Bibliográficos
Autores principales:	Bhattacharya, Arijit, Leprohon, Philippe, Ouellette, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104401/ https://www.ncbi.nlm.nih.gov/pubmed/33905412 http://dx.doi.org/10.1371/journal.pntd.0009377

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