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Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C

Chronic kidney disease (CKD) is one of the most well-known extrahepatic manifestations caused by hepatitis C infection (HCV). CKD is typically discovered at a late stage. HCV-nephropathy may show different histopathologic patterns, as both glomerular and tubulointerstitial damage have been described...

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Autores principales: Kaartinen, Kati, Vuoti, Sauli, Honkanen, Eero, Löyttyniemi, Eliisa, Singh, Ravinder, Färkkilä, Martti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104418/
https://www.ncbi.nlm.nih.gov/pubmed/33961672
http://dx.doi.org/10.1371/journal.pone.0251392
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author Kaartinen, Kati
Vuoti, Sauli
Honkanen, Eero
Löyttyniemi, Eliisa
Singh, Ravinder
Färkkilä, Martti
author_facet Kaartinen, Kati
Vuoti, Sauli
Honkanen, Eero
Löyttyniemi, Eliisa
Singh, Ravinder
Färkkilä, Martti
author_sort Kaartinen, Kati
collection PubMed
description Chronic kidney disease (CKD) is one of the most well-known extrahepatic manifestations caused by hepatitis C infection (HCV). CKD is typically discovered at a late stage. HCV-nephropathy may show different histopathologic patterns, as both glomerular and tubulointerstitial damage have been described. Identification of patients with early renal manifestations would be beneficial to provide treatment and avoid progression to CKD. The observational prospective single-center HCVKID study assessed the prevalence of early renal manifestations in patients with chronic HCV and compared these patients with HCV-negative healthy controls cross-sectionally. HCV-positive patients with and without renal manifestations were also compared to define biomarkers suitable for identifying early manifestations in standard clinical practice. Tubular proteinuria as judged by urine α 1-microglobulin was the most common early renal manifestation found in 11% in HCV-positive patients, followed by hematuria in 8%. Kidney filtration was statistically significantly lower among HCV-positive patients with renal manifestation according to any calculation method. There were no significant differences in duration of infection or stage of liver fibrosis between patients with or without renal manifestations. Tubular cell damage may be the earliest sign of renal dysfunction caused by HCV. Complement activation also correlates with the dysfunction, indicating of contribution to HCV-induced renal manifestations even in their early phase.
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spelling pubmed-81044182021-05-18 Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C Kaartinen, Kati Vuoti, Sauli Honkanen, Eero Löyttyniemi, Eliisa Singh, Ravinder Färkkilä, Martti PLoS One Research Article Chronic kidney disease (CKD) is one of the most well-known extrahepatic manifestations caused by hepatitis C infection (HCV). CKD is typically discovered at a late stage. HCV-nephropathy may show different histopathologic patterns, as both glomerular and tubulointerstitial damage have been described. Identification of patients with early renal manifestations would be beneficial to provide treatment and avoid progression to CKD. The observational prospective single-center HCVKID study assessed the prevalence of early renal manifestations in patients with chronic HCV and compared these patients with HCV-negative healthy controls cross-sectionally. HCV-positive patients with and without renal manifestations were also compared to define biomarkers suitable for identifying early manifestations in standard clinical practice. Tubular proteinuria as judged by urine α 1-microglobulin was the most common early renal manifestation found in 11% in HCV-positive patients, followed by hematuria in 8%. Kidney filtration was statistically significantly lower among HCV-positive patients with renal manifestation according to any calculation method. There were no significant differences in duration of infection or stage of liver fibrosis between patients with or without renal manifestations. Tubular cell damage may be the earliest sign of renal dysfunction caused by HCV. Complement activation also correlates with the dysfunction, indicating of contribution to HCV-induced renal manifestations even in their early phase. Public Library of Science 2021-05-07 /pmc/articles/PMC8104418/ /pubmed/33961672 http://dx.doi.org/10.1371/journal.pone.0251392 Text en © 2021 Kaartinen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kaartinen, Kati
Vuoti, Sauli
Honkanen, Eero
Löyttyniemi, Eliisa
Singh, Ravinder
Färkkilä, Martti
Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C
title Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C
title_full Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C
title_fullStr Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C
title_full_unstemmed Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C
title_short Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C
title_sort tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by hepatitis c
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104418/
https://www.ncbi.nlm.nih.gov/pubmed/33961672
http://dx.doi.org/10.1371/journal.pone.0251392
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