Overexpression of oncogenic H-Ras in hTERT-immortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion

DNA polymerases play essential functions in replication fork progression and genome maintenance. DNA lesions and drug-induced replication stress result in up-regulation and re-localization of specialized DNA polymerases η and κ. Although oncogene activation significantly alters DNA replication dynam...

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Detalles Bibliográficos
Autores principales: Tsao, Wei-chung, Buj, Raquel, Aird, Katherine M., Sidorova, Julia M., Eckert, Kristin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104423/
https://www.ncbi.nlm.nih.gov/pubmed/33961649
http://dx.doi.org/10.1371/journal.pone.0251188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104423/
https://www.ncbi.nlm.nih.gov/pubmed/33961649
http://dx.doi.org/10.1371/journal.pone.0251188

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