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Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review
The advent of affordable, portable ultrasound devices has led to increasing interest in the use of point-of-care ultrasound (POCUS) for the detection of pulmonary TB (PTB). We undertook a systematic review of the diagnostic accuracy of POCUS for PTB. Five databases were searched for articles publish...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104425/ https://www.ncbi.nlm.nih.gov/pubmed/33961639 http://dx.doi.org/10.1371/journal.pone.0251236 |
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author | Bigio, Jacob Kohli, Mikashmi Klinton, Joel Shyam MacLean, Emily Gore, Genevieve Small, Peter M. Ruhwald, Morten Weber, Stefan Fabian Jha, Saurabh Pai, Madhukar |
author_facet | Bigio, Jacob Kohli, Mikashmi Klinton, Joel Shyam MacLean, Emily Gore, Genevieve Small, Peter M. Ruhwald, Morten Weber, Stefan Fabian Jha, Saurabh Pai, Madhukar |
author_sort | Bigio, Jacob |
collection | PubMed |
description | The advent of affordable, portable ultrasound devices has led to increasing interest in the use of point-of-care ultrasound (POCUS) for the detection of pulmonary TB (PTB). We undertook a systematic review of the diagnostic accuracy of POCUS for PTB. Five databases were searched for articles published between January 2010 and June 2020. Risk of bias was assessed using QUADAS-2. Data on sensitivity and specificity of individual lung ultrasound findings were collected, with variable reference standards including PCR and sputum smear microscopy. Six of 3,919 reviewed articles were included: five in adults and one in children, with a total sample size of 564. Studies had high risk of bias in many domains. In adults, subpleural nodule and lung consolidation were the lung ultrasound findings with the highest sensitivities, ranging from 72.5% to 100.0% and 46.7% to 80.4%, respectively. Only one study reported specificity data. Variability in sensitivity may be due to variable reference standards or may imply operator dependence. There is insufficient evidence to judge the diagnostic accuracy of POCUS for PTB. There is also no consensus on the optimal protocols for acquiring and analysing POCUS images for PTB. New studies which minimise potential sources of bias are required to further assess the diagnostic accuracy of POCUS for PTB. |
format | Online Article Text |
id | pubmed-8104425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81044252021-05-18 Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review Bigio, Jacob Kohli, Mikashmi Klinton, Joel Shyam MacLean, Emily Gore, Genevieve Small, Peter M. Ruhwald, Morten Weber, Stefan Fabian Jha, Saurabh Pai, Madhukar PLoS One Research Article The advent of affordable, portable ultrasound devices has led to increasing interest in the use of point-of-care ultrasound (POCUS) for the detection of pulmonary TB (PTB). We undertook a systematic review of the diagnostic accuracy of POCUS for PTB. Five databases were searched for articles published between January 2010 and June 2020. Risk of bias was assessed using QUADAS-2. Data on sensitivity and specificity of individual lung ultrasound findings were collected, with variable reference standards including PCR and sputum smear microscopy. Six of 3,919 reviewed articles were included: five in adults and one in children, with a total sample size of 564. Studies had high risk of bias in many domains. In adults, subpleural nodule and lung consolidation were the lung ultrasound findings with the highest sensitivities, ranging from 72.5% to 100.0% and 46.7% to 80.4%, respectively. Only one study reported specificity data. Variability in sensitivity may be due to variable reference standards or may imply operator dependence. There is insufficient evidence to judge the diagnostic accuracy of POCUS for PTB. There is also no consensus on the optimal protocols for acquiring and analysing POCUS images for PTB. New studies which minimise potential sources of bias are required to further assess the diagnostic accuracy of POCUS for PTB. Public Library of Science 2021-05-07 /pmc/articles/PMC8104425/ /pubmed/33961639 http://dx.doi.org/10.1371/journal.pone.0251236 Text en © 2021 Bigio et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Bigio, Jacob Kohli, Mikashmi Klinton, Joel Shyam MacLean, Emily Gore, Genevieve Small, Peter M. Ruhwald, Morten Weber, Stefan Fabian Jha, Saurabh Pai, Madhukar Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review |
title | Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review |
title_full | Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review |
title_fullStr | Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review |
title_full_unstemmed | Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review |
title_short | Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review |
title_sort | diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: a systematic review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104425/ https://www.ncbi.nlm.nih.gov/pubmed/33961639 http://dx.doi.org/10.1371/journal.pone.0251236 |
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