NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

There is an urgent need to identify vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). PDAC cells acquire metabolic changes that augment NADPH production and cytosolic redox homeostasis. Here, we show that high NADPH levels drive activity of NADPH oxidase 4 (NOX4) expressed in the endoplasm...

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Detalles Bibliográficos
Autores principales: Jain, Pallavi, Dvorkin-Gheva, Anna, Mollen, Erik, Malbeteau, Lucie, Xie, Michael, Jessa, Fatima, Dhavarasa, Piriththiv, Chung, Stephen, Brown, Kevin R., Jang, Gun Ho, Vora, Parth, Notta, Faiyaz, Moffat, Jason, Hedley, David, Boutros, Paul C., Wouters, Bradly G., Koritzinsky, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104867/
https://www.ncbi.nlm.nih.gov/pubmed/33962950
http://dx.doi.org/10.1126/sciadv.abf7114

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