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Robust and distributed neural representation of action values

Studies in rats, monkeys, and humans have found action-value signals in multiple regions of the brain. These findings suggest that action-value signals encoded in these brain structures bias choices toward higher expected rewards. However, previous estimates of action-value signals might have been i...

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Autores principales: Shin, Eun Ju, Jang, Yunsil, Kim, Soyoun, Kim, Hoseok, Cai, Xinying, Lee, Hyunjung, Sul, Jung Hoon, Lee, Sung-Hyun, Chung, Yeonseung, Lee, Daeyeol, Jung, Min Whan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104958/
https://www.ncbi.nlm.nih.gov/pubmed/33876728
http://dx.doi.org/10.7554/eLife.53045
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author Shin, Eun Ju
Jang, Yunsil
Kim, Soyoun
Kim, Hoseok
Cai, Xinying
Lee, Hyunjung
Sul, Jung Hoon
Lee, Sung-Hyun
Chung, Yeonseung
Lee, Daeyeol
Jung, Min Whan
author_facet Shin, Eun Ju
Jang, Yunsil
Kim, Soyoun
Kim, Hoseok
Cai, Xinying
Lee, Hyunjung
Sul, Jung Hoon
Lee, Sung-Hyun
Chung, Yeonseung
Lee, Daeyeol
Jung, Min Whan
author_sort Shin, Eun Ju
collection PubMed
description Studies in rats, monkeys, and humans have found action-value signals in multiple regions of the brain. These findings suggest that action-value signals encoded in these brain structures bias choices toward higher expected rewards. However, previous estimates of action-value signals might have been inflated by serial correlations in neural activity and also by activity related to other decision variables. Here, we applied several statistical tests based on permutation and surrogate data to analyze neural activity recorded from the striatum, frontal cortex, and hippocampus. The results show that previously identified action-value signals in these brain areas cannot be entirely accounted for by concurrent serial correlations in neural activity and action value. We also found that neural activity related to action value is intermixed with signals related to other decision variables. Our findings provide strong evidence for broadly distributed neural signals related to action value throughout the brain.
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spelling pubmed-81049582021-05-11 Robust and distributed neural representation of action values Shin, Eun Ju Jang, Yunsil Kim, Soyoun Kim, Hoseok Cai, Xinying Lee, Hyunjung Sul, Jung Hoon Lee, Sung-Hyun Chung, Yeonseung Lee, Daeyeol Jung, Min Whan eLife Neuroscience Studies in rats, monkeys, and humans have found action-value signals in multiple regions of the brain. These findings suggest that action-value signals encoded in these brain structures bias choices toward higher expected rewards. However, previous estimates of action-value signals might have been inflated by serial correlations in neural activity and also by activity related to other decision variables. Here, we applied several statistical tests based on permutation and surrogate data to analyze neural activity recorded from the striatum, frontal cortex, and hippocampus. The results show that previously identified action-value signals in these brain areas cannot be entirely accounted for by concurrent serial correlations in neural activity and action value. We also found that neural activity related to action value is intermixed with signals related to other decision variables. Our findings provide strong evidence for broadly distributed neural signals related to action value throughout the brain. eLife Sciences Publications, Ltd 2021-04-20 /pmc/articles/PMC8104958/ /pubmed/33876728 http://dx.doi.org/10.7554/eLife.53045 Text en © 2021, Shin et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Shin, Eun Ju
Jang, Yunsil
Kim, Soyoun
Kim, Hoseok
Cai, Xinying
Lee, Hyunjung
Sul, Jung Hoon
Lee, Sung-Hyun
Chung, Yeonseung
Lee, Daeyeol
Jung, Min Whan
Robust and distributed neural representation of action values
title Robust and distributed neural representation of action values
title_full Robust and distributed neural representation of action values
title_fullStr Robust and distributed neural representation of action values
title_full_unstemmed Robust and distributed neural representation of action values
title_short Robust and distributed neural representation of action values
title_sort robust and distributed neural representation of action values
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104958/
https://www.ncbi.nlm.nih.gov/pubmed/33876728
http://dx.doi.org/10.7554/eLife.53045
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