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Protomer alignment modulates specificity of RNA substrate recognition by Ire1

The unfolded protein response (UPR) maintains protein folding homeostasis in the endoplasmic reticulum (ER). In metazoan cells, the Ire1 branch of the UPR initiates two functional outputs—non-conventional mRNA splicing and selective mRNA decay (RIDD). By contrast, Ire1 orthologs from Saccharomyces c...

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Detalles Bibliográficos
Autores principales:	Li, Weihan, Crotty, Kelly, Garrido Ruiz, Diego, Voorhies, Mark, Rivera, Carlos, Sil, Anita, Mullins, R Dyche, Jacobson, Matthew P, Peschek, Jirka, Walter, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104961/ https://www.ncbi.nlm.nih.gov/pubmed/33904404 http://dx.doi.org/10.7554/eLife.67425

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