Facing Cell Autophagy in Gastric Cancer – What Do We Know so Far?

Autophagy is a process by which misfolded proteins and damaged organelles in the lysosomes of tumor cells were degraded reusing decomposed substances and avoiding accumulation of large amounts of harmful substances. Here, the role of autophagy in the development of malignant transformation of gastri...

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Detalles Bibliográficos
Autores principales: Xiu, Ting, Guo, Qie, Jing, Fan-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104978/
https://www.ncbi.nlm.nih.gov/pubmed/33976565
http://dx.doi.org/10.2147/IJGM.S298705
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author Xiu, Ting
Guo, Qie
Jing, Fan-Bo
author_facet Xiu, Ting
Guo, Qie
Jing, Fan-Bo
author_sort Xiu, Ting
collection PubMed
description Autophagy is a process by which misfolded proteins and damaged organelles in the lysosomes of tumor cells were degraded reusing decomposed substances and avoiding accumulation of large amounts of harmful substances. Here, the role of autophagy in the development of malignant transformation of gastric tumors, and the underlying mechanisms involved in autophagy formation, and the application of targeted autophagy in the treatment of gastric cancer were summarized.
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spelling pubmed-81049782021-05-10 Facing Cell Autophagy in Gastric Cancer – What Do We Know so Far? Xiu, Ting Guo, Qie Jing, Fan-Bo Int J Gen Med Review Autophagy is a process by which misfolded proteins and damaged organelles in the lysosomes of tumor cells were degraded reusing decomposed substances and avoiding accumulation of large amounts of harmful substances. Here, the role of autophagy in the development of malignant transformation of gastric tumors, and the underlying mechanisms involved in autophagy formation, and the application of targeted autophagy in the treatment of gastric cancer were summarized. Dove 2021-05-03 /pmc/articles/PMC8104978/ /pubmed/33976565 http://dx.doi.org/10.2147/IJGM.S298705 Text en © 2021 Xiu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Xiu, Ting
Guo, Qie
Jing, Fan-Bo
Facing Cell Autophagy in Gastric Cancer – What Do We Know so Far?
title Facing Cell Autophagy in Gastric Cancer – What Do We Know so Far?
title_full Facing Cell Autophagy in Gastric Cancer – What Do We Know so Far?
title_fullStr Facing Cell Autophagy in Gastric Cancer – What Do We Know so Far?
title_full_unstemmed Facing Cell Autophagy in Gastric Cancer – What Do We Know so Far?
title_short Facing Cell Autophagy in Gastric Cancer – What Do We Know so Far?
title_sort facing cell autophagy in gastric cancer – what do we know so far?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104978/
https://www.ncbi.nlm.nih.gov/pubmed/33976565
http://dx.doi.org/10.2147/IJGM.S298705
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