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Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis
PURPOSE OF REVIEW: To review the current knowledge on interactions between dietary factors and microRNAs (miRNAs) in essential hypertension (EH) pathogenesis. RECENT FINDINGS: There exists an integration of maintenance signals generated by genetic, epigenetic, immune, and environmental (e.g., dietar...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105193/ https://www.ncbi.nlm.nih.gov/pubmed/33961141 http://dx.doi.org/10.1007/s11906-021-01142-9 |
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author | Golonka, Rachel M. Cooper, Johnathan Kawika Issa, Rochell Devarasetty, Pratyush Pavan Gokula, Veda Busken, Joshua Zubcevic, Jasenka Hill, Jennifer Vijay-Kumar, Matam Menon, Bindu Joe, Bina |
author_facet | Golonka, Rachel M. Cooper, Johnathan Kawika Issa, Rochell Devarasetty, Pratyush Pavan Gokula, Veda Busken, Joshua Zubcevic, Jasenka Hill, Jennifer Vijay-Kumar, Matam Menon, Bindu Joe, Bina |
author_sort | Golonka, Rachel M. |
collection | PubMed |
description | PURPOSE OF REVIEW: To review the current knowledge on interactions between dietary factors and microRNAs (miRNAs) in essential hypertension (EH) pathogenesis. RECENT FINDINGS: There exists an integration of maintenance signals generated by genetic, epigenetic, immune, and environmental (e.g., dietary) factors that work to sustain balance in the gut-liver axis. It is well established that an imbalance in this complex, intertwined system substantially increases the risk for EH. As such, pertinent research has been taken to decipher how each signal operates in isolation and together in EH progression. Recent literature indicates that both macro- and micronutrients interrupt regulatory miRNA expressions and thus, alter multiple cellular processes that contribute to EH and its comorbidities. We highlight how carbohydrates, lipids, proteins, salt, and potassium modify miRNA signatures during EH. The disruption in miRNA expression can negatively impact communication systems such as over activating the renin-angiotensin-aldosterone system, modulating the vascular smooth muscle cell phenotype, and promoting angiogenesis to favor EH. We also delineate the prognostic value of miRNAs in EH and discuss the pros and cons of surgical vs dietary prophylactic approaches in EH prevention. SUMMARY: We propose that dietary-dependent perturbation of the miRNA profile is one mechanism within the gut-liver axis that dictates EH development. |
format | Online Article Text |
id | pubmed-8105193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-81051932021-05-11 Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis Golonka, Rachel M. Cooper, Johnathan Kawika Issa, Rochell Devarasetty, Pratyush Pavan Gokula, Veda Busken, Joshua Zubcevic, Jasenka Hill, Jennifer Vijay-Kumar, Matam Menon, Bindu Joe, Bina Curr Hypertens Rep Prevention of Hypertension: Public Health Challenges (Y Yano, Section Editor) PURPOSE OF REVIEW: To review the current knowledge on interactions between dietary factors and microRNAs (miRNAs) in essential hypertension (EH) pathogenesis. RECENT FINDINGS: There exists an integration of maintenance signals generated by genetic, epigenetic, immune, and environmental (e.g., dietary) factors that work to sustain balance in the gut-liver axis. It is well established that an imbalance in this complex, intertwined system substantially increases the risk for EH. As such, pertinent research has been taken to decipher how each signal operates in isolation and together in EH progression. Recent literature indicates that both macro- and micronutrients interrupt regulatory miRNA expressions and thus, alter multiple cellular processes that contribute to EH and its comorbidities. We highlight how carbohydrates, lipids, proteins, salt, and potassium modify miRNA signatures during EH. The disruption in miRNA expression can negatively impact communication systems such as over activating the renin-angiotensin-aldosterone system, modulating the vascular smooth muscle cell phenotype, and promoting angiogenesis to favor EH. We also delineate the prognostic value of miRNAs in EH and discuss the pros and cons of surgical vs dietary prophylactic approaches in EH prevention. SUMMARY: We propose that dietary-dependent perturbation of the miRNA profile is one mechanism within the gut-liver axis that dictates EH development. Springer US 2021-05-07 2021 /pmc/articles/PMC8105193/ /pubmed/33961141 http://dx.doi.org/10.1007/s11906-021-01142-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Prevention of Hypertension: Public Health Challenges (Y Yano, Section Editor) Golonka, Rachel M. Cooper, Johnathan Kawika Issa, Rochell Devarasetty, Pratyush Pavan Gokula, Veda Busken, Joshua Zubcevic, Jasenka Hill, Jennifer Vijay-Kumar, Matam Menon, Bindu Joe, Bina Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis |
title | Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis |
title_full | Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis |
title_fullStr | Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis |
title_full_unstemmed | Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis |
title_short | Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis |
title_sort | impact of nutritional epigenetics in essential hypertension: targeting micrornas in the gut-liver axis |
topic | Prevention of Hypertension: Public Health Challenges (Y Yano, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105193/ https://www.ncbi.nlm.nih.gov/pubmed/33961141 http://dx.doi.org/10.1007/s11906-021-01142-9 |
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