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Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11

Minimally invasive surgery (MIS) has become the standard approach in early stage cervical cancer (ECC). However, the recently published “LACC” trial and even others could show inferior PFS and OS of MIS compared to open radical hysterectomy. The results led to a widespread debate about the best surg...

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Autores principales: Armbrust, Robert, Chen, Frank, Richter, Rolf, Muallem, Mustafa Zela, Mustea, Alexander, Holthaus, Bernd, Sehouli, Jalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105313/
https://www.ncbi.nlm.nih.gov/pubmed/33963213
http://dx.doi.org/10.1038/s41598-021-89071-0
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author Armbrust, Robert
Chen, Frank
Richter, Rolf
Muallem, Mustafa Zela
Mustea, Alexander
Holthaus, Bernd
Sehouli, Jalid
author_facet Armbrust, Robert
Chen, Frank
Richter, Rolf
Muallem, Mustafa Zela
Mustea, Alexander
Holthaus, Bernd
Sehouli, Jalid
author_sort Armbrust, Robert
collection PubMed
description Minimally invasive surgery (MIS) has become the standard approach in early stage cervical cancer (ECC). However, the recently published “LACC” trial and even others could show inferior PFS and OS of MIS compared to open radical hysterectomy. The results led to a widespread debate about the best surgical approach in ECC. The present survey aimed to get first insights after publication. NOGGO and AGE conducted a nationwide digital survey among 186 Gynecological Cancer Centers. Descriptive statistics and t-tests were performed using SPSS. A majority of the centers were of high expertise and/or experience in treatment of ECC and were highly aware of the LACC trial results. Trial quality and scientific value were rated as very good/good. However, still 40% would not change the standard of care to open surgery. Centers with higher volume and participating in clinical trials were more likely to change. This survey represents insights after the surprising results of recently published trials towards the surgical approach of ECC. There still seems to be a high need of future trials and possible explanations for the unexpected worse outcomes in the MIS group.
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spelling pubmed-81053132021-05-10 Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11 Armbrust, Robert Chen, Frank Richter, Rolf Muallem, Mustafa Zela Mustea, Alexander Holthaus, Bernd Sehouli, Jalid Sci Rep Article Minimally invasive surgery (MIS) has become the standard approach in early stage cervical cancer (ECC). However, the recently published “LACC” trial and even others could show inferior PFS and OS of MIS compared to open radical hysterectomy. The results led to a widespread debate about the best surgical approach in ECC. The present survey aimed to get first insights after publication. NOGGO and AGE conducted a nationwide digital survey among 186 Gynecological Cancer Centers. Descriptive statistics and t-tests were performed using SPSS. A majority of the centers were of high expertise and/or experience in treatment of ECC and were highly aware of the LACC trial results. Trial quality and scientific value were rated as very good/good. However, still 40% would not change the standard of care to open surgery. Centers with higher volume and participating in clinical trials were more likely to change. This survey represents insights after the surprising results of recently published trials towards the surgical approach of ECC. There still seems to be a high need of future trials and possible explanations for the unexpected worse outcomes in the MIS group. Nature Publishing Group UK 2021-05-07 /pmc/articles/PMC8105313/ /pubmed/33963213 http://dx.doi.org/10.1038/s41598-021-89071-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Armbrust, Robert
Chen, Frank
Richter, Rolf
Muallem, Mustafa Zela
Mustea, Alexander
Holthaus, Bernd
Sehouli, Jalid
Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11
title Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11
title_full Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11
title_fullStr Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11
title_full_unstemmed Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11
title_short Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11
title_sort results of a german wide survey towards current surgical approach in early stage cervical cancer noggo monitor 11
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105313/
https://www.ncbi.nlm.nih.gov/pubmed/33963213
http://dx.doi.org/10.1038/s41598-021-89071-0
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