Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma

Glaucoma of which primary open angle glaucoma (POAG) constitutes 75%, is the second leading cause of blindness. Elevated intra ocular pressure and Nitric oxide synthase (NOS) dysfunction are hallmarks of POAG. We analyzed clinical data, cytokine profile, ATP level, metabolomics and GEO datasets to i...

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Detalles Bibliográficos
Autores principales: Pulukool, Sujith Kumar, Bhagavatham, Sai Krishna Srimadh, Kannan, Vishnu, Sukumar, Piruthivi, Dandamudi, Rajesh Babu, Ghaisas, Shamika, Kunchala, Haripriya, Saieesh, Darshan, Naik, Ashwin Ashok, Pargaonkar, Ashish, Sharma, Anuj, Sivaramakrishnan, Venketesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105335/
https://www.ncbi.nlm.nih.gov/pubmed/33963197
http://dx.doi.org/10.1038/s41598-021-89137-z

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