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Low human dystrophin levels prevent cardiac electrophysiological and structural remodelling in a Duchenne mouse model
Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder caused by loss of dystrophin. This lack also affects cardiac structure and function, and cardiovascular complications are a major cause of death in DMD. Newly developed therapies partially restore dystrophin expression. It is...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105358/ https://www.ncbi.nlm.nih.gov/pubmed/33963238 http://dx.doi.org/10.1038/s41598-021-89208-1 |