Low human dystrophin levels prevent cardiac electrophysiological and structural remodelling in a Duchenne mouse model

Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder caused by loss of dystrophin. This lack also affects cardiac structure and function, and cardiovascular complications are a major cause of death in DMD. Newly developed therapies partially restore dystrophin expression. It is...

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Detalles Bibliográficos
Autores principales: Marchal, Gerard A., van Putten, Maaike, Verkerk, Arie O., Casini, Simona, Putker, Kayleigh, van Amersfoorth, Shirley C. M., Aartsma-Rus, Annemieke, Lodder, Elisabeth M., Remme, Carol Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105358/
https://www.ncbi.nlm.nih.gov/pubmed/33963238
http://dx.doi.org/10.1038/s41598-021-89208-1

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