Cargando…
Anti-Tat immunity defines CD4(+) T-cell dynamics in people living with HIV on long-term cART.
BACKGROUND: Low-level HIV viremia originating from virus reactivation in HIV reservoirs is often present in cART treated individuals and represents a persisting source of immune stimulation associated with sub-optimal recovery of CD4(+) T cells. The HIV-1 Tat protein is released in the extracellular...
Autores principales: | Tripiciano, Antonella, Picconi, Orietta, Moretti, Sonia, Sgadari, Cecilia, Cafaro, Aurelio, Francavilla, Vittorio, Arancio, Angela, Paniccia, Giovanni, Campagna, Massimo, Pavone-Cossut, Maria Rosaria, Sighinolfi, Laura, Latini, Alessandra, Mercurio, Vito S., Pietro, Massimo Di, Castelli, Francesco, Saracino, Annalisa, Mussini, Cristina, Perri, Giovanni Di, Galli, Massimo, Nozza, Silvia, Ensoli, Fabrizio, Monini, Paolo, Ensoli, Barbara |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105504/ https://www.ncbi.nlm.nih.gov/pubmed/33839064 http://dx.doi.org/10.1016/j.ebiom.2021.103306 |
Ejemplares similares
-
Continued Decay of HIV Proviral DNA Upon Vaccination With HIV-1 Tat of Subjects on Long-Term ART: An 8-Year Follow-Up Study
por: Sgadari, Cecilia, et al.
Publicado: (2019) -
HIV-1 Tat Protein Enters Dysfunctional Endothelial Cells via Integrins and Renders Them Permissive to Virus Replication
por: Cafaro, Aurelio, et al.
Publicado: (2020) -
The presence of anti-Tat antibodies in HIV-infected individuals is associated with containment of CD4(+) T-cell decay and viral load, and with delay of disease progression: results of a 3-year cohort study
por: Bellino, Stefania, et al.
Publicado: (2014) -
Anti-Tat Immunity in HIV-1 Infection: Effects of Naturally Occurring and Vaccine-Induced Antibodies Against Tat on the Course of the Disease
por: Cafaro, Aurelio, et al.
Publicado: (2019) -
HIV-1 Tat immunization restores immune homeostasis and attacks the HAART-resistant blood HIV DNA: results of a randomized phase II exploratory clinical trial
por: Ensoli, Fabrizio, et al.
Publicado: (2015)