G protein β5-ATM complexes drive acetaminophen-induced hepatotoxicity

Excessive ingestion of the common analgesic acetaminophen (APAP) leads to severe hepatotoxicity. Here we identify G protein β5 (Gβ(5)), elevated in livers from APAP overdose patients, as a critical regulator of cell death pathways and autophagic signaling in APAP-exposed liver. Liver-specific knockd...

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Detalles Bibliográficos
Autores principales: Pramanick, Arnab, Chakraborti, Sreemoyee, Mahata, Tarun, Basak, Madhuri, Das, Kiran, Verma, Sumit Kumar, Sengar, Abhishek Singh, Singh, Praveen Kumar, Kumar, Pranesh, Bhattacharya, Bolay, Biswas, Sayan, Pal, Parag Baran, Sarkar, Subhasish, Agrawal, Vinita, Saha, Sudipta, Nath, Debjani, Chatterjee, Suvro, Stewart, Adele, Maity, Biswanath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105674/
https://www.ncbi.nlm.nih.gov/pubmed/33933881
http://dx.doi.org/10.1016/j.redox.2021.101965

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