Unconventional voltage sensing in an inwardly rectifying potassium channel

Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-dependent block by polyamines. A surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels suggests a mechanism...

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Detalles Bibliográficos
Autor principal: Kurata, Harley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105720/
https://www.ncbi.nlm.nih.gov/pubmed/33956072
http://dx.doi.org/10.1085/jgp.202112929
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author Kurata, Harley T.
author_facet Kurata, Harley T.
author_sort Kurata, Harley T.
collection PubMed
description Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-dependent block by polyamines. A surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels suggests a mechanism of voltage dependence arising from interactions with permeating ions.
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spelling pubmed-81057202021-12-07 Unconventional voltage sensing in an inwardly rectifying potassium channel Kurata, Harley T. J Gen Physiol Commentary Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-dependent block by polyamines. A surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels suggests a mechanism of voltage dependence arising from interactions with permeating ions. Rockefeller University Press 2021-05-06 /pmc/articles/PMC8105720/ /pubmed/33956072 http://dx.doi.org/10.1085/jgp.202112929 Text en © 2021 Kurata http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Kurata, Harley T.
Unconventional voltage sensing in an inwardly rectifying potassium channel
title Unconventional voltage sensing in an inwardly rectifying potassium channel
title_full Unconventional voltage sensing in an inwardly rectifying potassium channel
title_fullStr Unconventional voltage sensing in an inwardly rectifying potassium channel
title_full_unstemmed Unconventional voltage sensing in an inwardly rectifying potassium channel
title_short Unconventional voltage sensing in an inwardly rectifying potassium channel
title_sort unconventional voltage sensing in an inwardly rectifying potassium channel
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105720/
https://www.ncbi.nlm.nih.gov/pubmed/33956072
http://dx.doi.org/10.1085/jgp.202112929
work_keys_str_mv AT kurataharleyt unconventionalvoltagesensinginaninwardlyrectifyingpotassiumchannel

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