Cargando…
Biological drug and drug delivery-mediated immunotherapy
The initiation and development of major inflammatory diseases, i.e., cancer, vascular inflammation, and some autoimmune diseases are closely linked to the immune system. Biologics-based immunotherapy is exerting a critical role against these diseases, whereas the usage of the immunomodulators is alw...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105778/ https://www.ncbi.nlm.nih.gov/pubmed/33996408 http://dx.doi.org/10.1016/j.apsb.2020.12.018 |
_version_ | 1783689668116611072 |
---|---|
author | Xiao, Qingqing Li, Xiaotong Li, Yi Wu, Zhenfeng Xu, Chenjie Chen, Zhongjian He, Wei |
author_facet | Xiao, Qingqing Li, Xiaotong Li, Yi Wu, Zhenfeng Xu, Chenjie Chen, Zhongjian He, Wei |
author_sort | Xiao, Qingqing |
collection | PubMed |
description | The initiation and development of major inflammatory diseases, i.e., cancer, vascular inflammation, and some autoimmune diseases are closely linked to the immune system. Biologics-based immunotherapy is exerting a critical role against these diseases, whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo, poor penetration across biological barriers, and rapid clearance by the reticuloendothelial system. Drug delivery strategies are potent to promote their delivery. Herein, we reviewed the potential targets for immunotherapy against the major inflammatory diseases, discussed the biologics and drug delivery systems involved in the immunotherapy, particularly highlighted the approved therapy tactics, and finally offer perspectives in this field. |
format | Online Article Text |
id | pubmed-8105778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81057782021-05-14 Biological drug and drug delivery-mediated immunotherapy Xiao, Qingqing Li, Xiaotong Li, Yi Wu, Zhenfeng Xu, Chenjie Chen, Zhongjian He, Wei Acta Pharm Sin B Review The initiation and development of major inflammatory diseases, i.e., cancer, vascular inflammation, and some autoimmune diseases are closely linked to the immune system. Biologics-based immunotherapy is exerting a critical role against these diseases, whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo, poor penetration across biological barriers, and rapid clearance by the reticuloendothelial system. Drug delivery strategies are potent to promote their delivery. Herein, we reviewed the potential targets for immunotherapy against the major inflammatory diseases, discussed the biologics and drug delivery systems involved in the immunotherapy, particularly highlighted the approved therapy tactics, and finally offer perspectives in this field. Elsevier 2021-04 2020-12-31 /pmc/articles/PMC8105778/ /pubmed/33996408 http://dx.doi.org/10.1016/j.apsb.2020.12.018 Text en © 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Xiao, Qingqing Li, Xiaotong Li, Yi Wu, Zhenfeng Xu, Chenjie Chen, Zhongjian He, Wei Biological drug and drug delivery-mediated immunotherapy |
title | Biological drug and drug delivery-mediated immunotherapy |
title_full | Biological drug and drug delivery-mediated immunotherapy |
title_fullStr | Biological drug and drug delivery-mediated immunotherapy |
title_full_unstemmed | Biological drug and drug delivery-mediated immunotherapy |
title_short | Biological drug and drug delivery-mediated immunotherapy |
title_sort | biological drug and drug delivery-mediated immunotherapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105778/ https://www.ncbi.nlm.nih.gov/pubmed/33996408 http://dx.doi.org/10.1016/j.apsb.2020.12.018 |
work_keys_str_mv | AT xiaoqingqing biologicaldruganddrugdeliverymediatedimmunotherapy AT lixiaotong biologicaldruganddrugdeliverymediatedimmunotherapy AT liyi biologicaldruganddrugdeliverymediatedimmunotherapy AT wuzhenfeng biologicaldruganddrugdeliverymediatedimmunotherapy AT xuchenjie biologicaldruganddrugdeliverymediatedimmunotherapy AT chenzhongjian biologicaldruganddrugdeliverymediatedimmunotherapy AT hewei biologicaldruganddrugdeliverymediatedimmunotherapy |