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Trigeminal Neuralgia TRPM8 Mutation: Enhanced Activation, Basal [Ca(2+)](i) and Menthol Response

OBJECTIVE: To assess the functional effects of a variant, c.89 G > A (p.Arg30Gln), in the transient receptor potential melastatin 8 (TRPM8) cold-sensing, nonselective cation channel, which we have previously identified in a patient with familial trigeminal neuralgia. METHODS: We carried out Ca(2+...

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Detalles Bibliográficos
Autores principales:	Gualdani, Roberta, Yuan, Jun-Hui, Effraim, Philip R., Di Stefano, Giulia, Truini, Andrea, Cruccu, Giorgio, Dib-Hajj, Sulayman D., Gailly, Philippe, Waxman, Stephen G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105906/ https://www.ncbi.nlm.nih.gov/pubmed/33977138 http://dx.doi.org/10.1212/NXG.0000000000000550

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