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MAP, Johne’s disease and the microbiome; current knowledge and future considerations

Mycobacterium avium subsp. paratuberculosis is the causative agent of Johne’s disease in ruminants. As an infectious disease that causes reduced milk yields, effects fertility and, eventually, the loss of the animal, it is a huge financial burden for associated industries. Efforts to control MAP inf...

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Autores principales: Matthews, Chloe, Cotter, Paul D., O’ Mahony, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105914/
https://www.ncbi.nlm.nih.gov/pubmed/33962690
http://dx.doi.org/10.1186/s42523-021-00089-1
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author Matthews, Chloe
Cotter, Paul D.
O’ Mahony, Jim
author_facet Matthews, Chloe
Cotter, Paul D.
O’ Mahony, Jim
author_sort Matthews, Chloe
collection PubMed
description Mycobacterium avium subsp. paratuberculosis is the causative agent of Johne’s disease in ruminants. As an infectious disease that causes reduced milk yields, effects fertility and, eventually, the loss of the animal, it is a huge financial burden for associated industries. Efforts to control MAP infection and Johne’s disease are complicated due to difficulties of diagnosis in the early stages of infection and challenges relating to the specificity and sensitivity of current testing methods. The methods that are available contribute to widely used test and cull strategies, vaccination programmes also in place in some countries. Next generation sequencing technologies have opened up new avenues for the discovery of novel biomarkers for disease prediction within MAP genomes and within ruminant microbiomes. Controlling Johne’s disease in herds can lead to improved animal health and welfare, in turn leading to increased productivity. With current climate change bills, such as the European Green Deal, targeting livestock production systems for more sustainable practices, managing animal health is now more important than ever before. This review provides an overview of the current knowledge on genomics and detection of MAP as it pertains to Johne’s disease.
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spelling pubmed-81059142021-05-10 MAP, Johne’s disease and the microbiome; current knowledge and future considerations Matthews, Chloe Cotter, Paul D. O’ Mahony, Jim Anim Microbiome Review Mycobacterium avium subsp. paratuberculosis is the causative agent of Johne’s disease in ruminants. As an infectious disease that causes reduced milk yields, effects fertility and, eventually, the loss of the animal, it is a huge financial burden for associated industries. Efforts to control MAP infection and Johne’s disease are complicated due to difficulties of diagnosis in the early stages of infection and challenges relating to the specificity and sensitivity of current testing methods. The methods that are available contribute to widely used test and cull strategies, vaccination programmes also in place in some countries. Next generation sequencing technologies have opened up new avenues for the discovery of novel biomarkers for disease prediction within MAP genomes and within ruminant microbiomes. Controlling Johne’s disease in herds can lead to improved animal health and welfare, in turn leading to increased productivity. With current climate change bills, such as the European Green Deal, targeting livestock production systems for more sustainable practices, managing animal health is now more important than ever before. This review provides an overview of the current knowledge on genomics and detection of MAP as it pertains to Johne’s disease. BioMed Central 2021-05-07 /pmc/articles/PMC8105914/ /pubmed/33962690 http://dx.doi.org/10.1186/s42523-021-00089-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Matthews, Chloe
Cotter, Paul D.
O’ Mahony, Jim
MAP, Johne’s disease and the microbiome; current knowledge and future considerations
title MAP, Johne’s disease and the microbiome; current knowledge and future considerations
title_full MAP, Johne’s disease and the microbiome; current knowledge and future considerations
title_fullStr MAP, Johne’s disease and the microbiome; current knowledge and future considerations
title_full_unstemmed MAP, Johne’s disease and the microbiome; current knowledge and future considerations
title_short MAP, Johne’s disease and the microbiome; current knowledge and future considerations
title_sort map, johne’s disease and the microbiome; current knowledge and future considerations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105914/
https://www.ncbi.nlm.nih.gov/pubmed/33962690
http://dx.doi.org/10.1186/s42523-021-00089-1
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