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Efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal Cancer: a retrospective study
BACKGROUND: The presence of lateral pelvic lymph node (LLN) metastasis is an essential prognostic factor in rectal cancer patients. Thus, preoperative diagnosis of LLN metastasis is clinically important to determine the therapeutic strategy. The aim of this study was to evaluate the efficacy of preo...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105987/ https://www.ncbi.nlm.nih.gov/pubmed/33962569 http://dx.doi.org/10.1186/s12885-021-08278-6 |
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author | Yukimoto, Ryohei Uemura, Mamoru Tsuboyama, Takahiro Hata, Tsuyoshi Fujino, Shiki Ogino, Takayuki Miyoshi, Norikatsu Takahashi, Hidekazu Hata, Taishi Yamamoto, Hirofumi Mizushima, Tsunekazu Kida, Akira Furuyashiki, Mamoru Doki, Yuichiro Eguchi, Hidetoshi |
author_facet | Yukimoto, Ryohei Uemura, Mamoru Tsuboyama, Takahiro Hata, Tsuyoshi Fujino, Shiki Ogino, Takayuki Miyoshi, Norikatsu Takahashi, Hidekazu Hata, Taishi Yamamoto, Hirofumi Mizushima, Tsunekazu Kida, Akira Furuyashiki, Mamoru Doki, Yuichiro Eguchi, Hidetoshi |
author_sort | Yukimoto, Ryohei |
collection | PubMed |
description | BACKGROUND: The presence of lateral pelvic lymph node (LLN) metastasis is an essential prognostic factor in rectal cancer patients. Thus, preoperative diagnosis of LLN metastasis is clinically important to determine the therapeutic strategy. The aim of this study was to evaluate the efficacy of preoperative positron emission tomography/computed tomography (PET/CT) in the diagnosis of LLN metastasis. METHODS: Eighty-four patients with rectal cancer who underwent LLN dissection at Osaka University were included in this study. The maximum standardized uptake value (SUV(max)) of the primary tumor and LLN were preoperatively calculated using PET/CT. Simultaneously, the short axis of the lymph node was measured using multi-detector row computed tomography (MDCT). The presence of metastases was evaluated by postoperative pathological examination. RESULTS: Of the 84 patients, LLN metastases developed in the left, right, and both LLN regions in 6, 7, and 2 patients, respectively. The diagnosis of the metastases was predicted with a sensitivity of 82%, specificity of 93%, positive predictive value of 58%, negative predictive value of 98%, false positive value of 7%, and false negative value of 18% when the cutoff value of the LLN SUV(max) was set at 1.5. The cutoff value of the short axis set at 7 mm on MDCT was most useful in diagnosing LLN metastases, but SUV(max) was even more useful in terms of specificity. CONCLUSIONS: The cutoff value of 1.5 for lymph node SUV(max) in PET is a reasonable measure to predict the risk of preoperative LLN metastases in rectal cancer patients. |
format | Online Article Text |
id | pubmed-8105987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81059872021-05-10 Efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal Cancer: a retrospective study Yukimoto, Ryohei Uemura, Mamoru Tsuboyama, Takahiro Hata, Tsuyoshi Fujino, Shiki Ogino, Takayuki Miyoshi, Norikatsu Takahashi, Hidekazu Hata, Taishi Yamamoto, Hirofumi Mizushima, Tsunekazu Kida, Akira Furuyashiki, Mamoru Doki, Yuichiro Eguchi, Hidetoshi BMC Cancer Research BACKGROUND: The presence of lateral pelvic lymph node (LLN) metastasis is an essential prognostic factor in rectal cancer patients. Thus, preoperative diagnosis of LLN metastasis is clinically important to determine the therapeutic strategy. The aim of this study was to evaluate the efficacy of preoperative positron emission tomography/computed tomography (PET/CT) in the diagnosis of LLN metastasis. METHODS: Eighty-four patients with rectal cancer who underwent LLN dissection at Osaka University were included in this study. The maximum standardized uptake value (SUV(max)) of the primary tumor and LLN were preoperatively calculated using PET/CT. Simultaneously, the short axis of the lymph node was measured using multi-detector row computed tomography (MDCT). The presence of metastases was evaluated by postoperative pathological examination. RESULTS: Of the 84 patients, LLN metastases developed in the left, right, and both LLN regions in 6, 7, and 2 patients, respectively. The diagnosis of the metastases was predicted with a sensitivity of 82%, specificity of 93%, positive predictive value of 58%, negative predictive value of 98%, false positive value of 7%, and false negative value of 18% when the cutoff value of the LLN SUV(max) was set at 1.5. The cutoff value of the short axis set at 7 mm on MDCT was most useful in diagnosing LLN metastases, but SUV(max) was even more useful in terms of specificity. CONCLUSIONS: The cutoff value of 1.5 for lymph node SUV(max) in PET is a reasonable measure to predict the risk of preoperative LLN metastases in rectal cancer patients. BioMed Central 2021-05-08 /pmc/articles/PMC8105987/ /pubmed/33962569 http://dx.doi.org/10.1186/s12885-021-08278-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yukimoto, Ryohei Uemura, Mamoru Tsuboyama, Takahiro Hata, Tsuyoshi Fujino, Shiki Ogino, Takayuki Miyoshi, Norikatsu Takahashi, Hidekazu Hata, Taishi Yamamoto, Hirofumi Mizushima, Tsunekazu Kida, Akira Furuyashiki, Mamoru Doki, Yuichiro Eguchi, Hidetoshi Efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal Cancer: a retrospective study |
title | Efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal Cancer: a retrospective study |
title_full | Efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal Cancer: a retrospective study |
title_fullStr | Efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal Cancer: a retrospective study |
title_full_unstemmed | Efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal Cancer: a retrospective study |
title_short | Efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal Cancer: a retrospective study |
title_sort | efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal cancer: a retrospective study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105987/ https://www.ncbi.nlm.nih.gov/pubmed/33962569 http://dx.doi.org/10.1186/s12885-021-08278-6 |
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