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A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2

BACKGROUND: No universal classification method for intrahepatic cholangiocarcinoma (IHCC) has been reported based on the embryological origin of biliary epithelial cells. The aim of this study was to classify IHCC according to protein expression levels of somatostatin receptor 2 (SSTR2) and b-cell l...

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Autores principales: Yamashita, Shoko, Morine, Yuji, Imura, Satoru, Ikemoto, Tetsuya, Saito, Yu, Takasu, Chie, Yamada, Shinichiro, Tokuda, Kazunori, Okikawa, Shohei, Miyazaki, Katsuki, Oya, Takeshi, Tsuneyama, Koichi, Shimada, Mitsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106133/
https://www.ncbi.nlm.nih.gov/pubmed/33962620
http://dx.doi.org/10.1186/s12957-021-02216-3
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author Yamashita, Shoko
Morine, Yuji
Imura, Satoru
Ikemoto, Tetsuya
Saito, Yu
Takasu, Chie
Yamada, Shinichiro
Tokuda, Kazunori
Okikawa, Shohei
Miyazaki, Katsuki
Oya, Takeshi
Tsuneyama, Koichi
Shimada, Mitsuo
author_facet Yamashita, Shoko
Morine, Yuji
Imura, Satoru
Ikemoto, Tetsuya
Saito, Yu
Takasu, Chie
Yamada, Shinichiro
Tokuda, Kazunori
Okikawa, Shohei
Miyazaki, Katsuki
Oya, Takeshi
Tsuneyama, Koichi
Shimada, Mitsuo
author_sort Yamashita, Shoko
collection PubMed
description BACKGROUND: No universal classification method for intrahepatic cholangiocarcinoma (IHCC) has been reported based on the embryological origin of biliary epithelial cells. The aim of this study was to classify IHCC according to protein expression levels of somatostatin receptor 2 (SSTR2) and b-cell leukemia/lymphoma 2 (Bcl2) and to elucidate the clinicopathological features of each group. METHODS: Fifty-two IHCC patients who underwent hepatic resection were enrolled in this study. Protein expression levels of SSTR2 and Bcl2 were examined using immunohistochemistry. Clinicopathological factors were compared between the three groups and prognostic factors were investigated. RESULTS: The patients were divided into three groups: SSTR2 positive and Bcl2 negative (p-Group H, n = 21), SSTR2 negative and Bcl2 positive (p-Group P, n = 14), and the indeterminate group (p-Group U, n = 17) for cases where SSTR2 and Bcl2 were both positive or both negative. All p-Group P cases displayed curability A or B. The 5-year survival rates of p-Group H and U patients were worse than those in p-Group P. p-Group H had higher T-factor, clinical stage, and incidence of periductal infiltration than p-Group P. CONCLUSIONS: This method could be used to classify IHCC into peripheral and perihilar type by embryological expression patterns of SSTR2 and Bcl2.
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spelling pubmed-81061332021-05-10 A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2 Yamashita, Shoko Morine, Yuji Imura, Satoru Ikemoto, Tetsuya Saito, Yu Takasu, Chie Yamada, Shinichiro Tokuda, Kazunori Okikawa, Shohei Miyazaki, Katsuki Oya, Takeshi Tsuneyama, Koichi Shimada, Mitsuo World J Surg Oncol Research BACKGROUND: No universal classification method for intrahepatic cholangiocarcinoma (IHCC) has been reported based on the embryological origin of biliary epithelial cells. The aim of this study was to classify IHCC according to protein expression levels of somatostatin receptor 2 (SSTR2) and b-cell leukemia/lymphoma 2 (Bcl2) and to elucidate the clinicopathological features of each group. METHODS: Fifty-two IHCC patients who underwent hepatic resection were enrolled in this study. Protein expression levels of SSTR2 and Bcl2 were examined using immunohistochemistry. Clinicopathological factors were compared between the three groups and prognostic factors were investigated. RESULTS: The patients were divided into three groups: SSTR2 positive and Bcl2 negative (p-Group H, n = 21), SSTR2 negative and Bcl2 positive (p-Group P, n = 14), and the indeterminate group (p-Group U, n = 17) for cases where SSTR2 and Bcl2 were both positive or both negative. All p-Group P cases displayed curability A or B. The 5-year survival rates of p-Group H and U patients were worse than those in p-Group P. p-Group H had higher T-factor, clinical stage, and incidence of periductal infiltration than p-Group P. CONCLUSIONS: This method could be used to classify IHCC into peripheral and perihilar type by embryological expression patterns of SSTR2 and Bcl2. BioMed Central 2021-05-07 /pmc/articles/PMC8106133/ /pubmed/33962620 http://dx.doi.org/10.1186/s12957-021-02216-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yamashita, Shoko
Morine, Yuji
Imura, Satoru
Ikemoto, Tetsuya
Saito, Yu
Takasu, Chie
Yamada, Shinichiro
Tokuda, Kazunori
Okikawa, Shohei
Miyazaki, Katsuki
Oya, Takeshi
Tsuneyama, Koichi
Shimada, Mitsuo
A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2
title A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2
title_full A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2
title_fullStr A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2
title_full_unstemmed A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2
title_short A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2
title_sort new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of sstr2 and bcl2
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106133/
https://www.ncbi.nlm.nih.gov/pubmed/33962620
http://dx.doi.org/10.1186/s12957-021-02216-3
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