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Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?

Forkhead box protein O1 (FoXO1) is a transcription factor involved in the regulation of a wide variety of physiological process including glucose metabolism, lipogenesis, bone mass, apoptosis, and autophagy. FoXO1 dysfunction is involved in the pathophysiology of various diseases including metabolic...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaojun, Jiang, Lusheng, Liu, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106445/
https://www.ncbi.nlm.nih.gov/pubmed/33976536
http://dx.doi.org/10.2147/DDDT.S305016
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author Zhang, Xiaojun
Jiang, Lusheng
Liu, Huimin
author_facet Zhang, Xiaojun
Jiang, Lusheng
Liu, Huimin
author_sort Zhang, Xiaojun
collection PubMed
description Forkhead box protein O1 (FoXO1) is a transcription factor involved in the regulation of a wide variety of physiological process including glucose metabolism, lipogenesis, bone mass, apoptosis, and autophagy. FoXO1 dysfunction is involved in the pathophysiology of various diseases including metabolic diseases, atherosclerosis, and tumors. FoXO1 activity is regulated in response to different physiological or pathogenic conditions by changes in protein expression and post-translational modifications. Various modifications cooperate to regulate FoXO1 activity and FoXO1 target gene transcription. In this review, we summarize how different post-translational modifications regulate FoXO1 physiological function, which may provide new insights for drug design and development.
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spelling pubmed-81064452021-05-10 Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target? Zhang, Xiaojun Jiang, Lusheng Liu, Huimin Drug Des Devel Ther Review Forkhead box protein O1 (FoXO1) is a transcription factor involved in the regulation of a wide variety of physiological process including glucose metabolism, lipogenesis, bone mass, apoptosis, and autophagy. FoXO1 dysfunction is involved in the pathophysiology of various diseases including metabolic diseases, atherosclerosis, and tumors. FoXO1 activity is regulated in response to different physiological or pathogenic conditions by changes in protein expression and post-translational modifications. Various modifications cooperate to regulate FoXO1 activity and FoXO1 target gene transcription. In this review, we summarize how different post-translational modifications regulate FoXO1 physiological function, which may provide new insights for drug design and development. Dove 2021-05-03 /pmc/articles/PMC8106445/ /pubmed/33976536 http://dx.doi.org/10.2147/DDDT.S305016 Text en © 2021 Zhang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Zhang, Xiaojun
Jiang, Lusheng
Liu, Huimin
Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?
title Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?
title_full Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?
title_fullStr Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?
title_full_unstemmed Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?
title_short Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?
title_sort forkhead box protein o1: functional diversity and post-translational modification, a new therapeutic target?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106445/
https://www.ncbi.nlm.nih.gov/pubmed/33976536
http://dx.doi.org/10.2147/DDDT.S305016
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