Cargando…

Ulinastatin Exhibits Antinociception in Rat Models of Acute Somatic and Visceral Pain Through Inhibiting the Local and Central Inflammation

INTRODUCTION: Ulinastatin, a broad-spectrum serine protease inhibitor, has been widely used to treat various diseases clinically. However, so far, the antinociceptive effect of ulinastatin remains less studied experimentally and the underlying mechanisms of ulinastatin for pain relief remain unclear...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhan, Mei-Xiang, Tang, Li, Lu, Yun-Fei, Wu, Huang-Hui, Guo, Zhi-Bin, Shi, Zhong-Mou, Yang, Chen-Long, Zou, Yi-Qing, Yang, Fei, Chen, Guo-Zhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106509/ https://www.ncbi.nlm.nih.gov/pubmed/33976570 http://dx.doi.org/10.2147/JPR.S303595

Ejemplares similares

(-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in μ-opioid receptor knockout mice
por: Ide, Soichiro, et al.
Publicado: (2011)

Treatment of patients with Covid-19 with a high dose of ulinastatin
por: Huang, Hai, et al.
Publicado: (2022)

Evaluation of the Pharmacological Function of Ulinastatin in Experimental Animals
por: Xu, Chong-En, et al.
Publicado: (2012)

Long-Term Exposure to Morphine Induces Cross-Tolerance to Acute Antinociceptive Effect of Remifentanil on Somatic and Visceral Stimuli in Rats
por: Mori, Hideaki, et al.
Publicado: (2022)

Ulinastatin attenuates lipopolysaccharide-induced cardiac dysfunction by inhibiting inflammation and regulating autophagy
por: Zhao, Pin, et al.
Publicado: (2020)

Effects of ulinastatin on global ischemia via brain pro-inflammation signal
por: Jiang, Xiao-Ming, et al.
Publicado: (2016)

Ulinastatin attenuates diabetes-induced cardiac dysfunction by the inhibition of inflammation and apoptosis
por: Wang, Wen-Ke, et al.
Publicado: (2017)

Ulinastatin Inhibits Osteoclastogenesis and Suppresses Ovariectomy-Induced Bone Loss by Downregulating uPAR
por: Huang, Jun-ming, et al.
Publicado: (2018)

Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis
por: Shan, Ren-Fei, et al.
Publicado: (2021)

Characterization of the Visceral Antinociceptive Effect of Glial Glutamate Transporter GLT-1 Upregulation by Ceftriaxone
por: Roman, K., et al.
Publicado: (2012)

PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects
por: Kleczkowska, Patrycja, et al.
Publicado: (2010)

Corrigendum: Ulinastatin Inhibits Osteoclastogenesis and Suppresses Ovariectomy-Induced Bone Loss by Downregulating uPAR
por: Huang, Jun-ming, et al.
Publicado: (2018)

Efficacy and Safety of Xuebijing Injection Combined With Ulinastatin as Adjunctive Therapy on Sepsis: A Systematic Review and Meta-Analysis
por: Chen, Guochao, et al.
Publicado: (2018)

Ulinastatin ameliorates tissue damage of severe acute pancreatitis through modulating regulatory T cells
por: Pan, Yu, et al.
Publicado: (2017)

Effects of ulinastatin combined with mechanical ventilation on oxygen metabolism, inflammation and stress response and antioxidant capacity of ARDS
por: Ji, Mingxia, et al.
Publicado: (2018)

Effect of Ulinastatin in the Treatment of Postperative Cognitive Dysfunction: Review of Current Literature
por: Lv, Zheng-tao, et al.
Publicado: (2016)

Beneficial effects of ulinastatin on gut barrier function in sepsis
por: Jiang, Longyuan, et al.
Publicado: (2013)

Effect of high-dose ulinastatin on the cardiopulmonary bypass-induced inflammatory response in patients undergoing open-heart surgery
por: Liu, Yu, et al.
Publicado: (2020)

Clinical observation of ulinastatin combined with CRRT in the treatment of early cardiopulmonary resuscitation
por: Liu, Qinghong, et al.
Publicado: (2017)

Protective effect of rhubarb combined with ulinastatin for patients with sepsis
por: Meng, Fulei, et al.
Publicado: (2020)

Ulinastatin alleviates traumatic brain injury by reducing endothelin-1
por: Liu, Ting, et al.
Publicado: (2021)

Does Intraoperative Ulinastatin Improve Postoperative Clinical Outcomes in Patients Undergoing Cardiac Surgery: A Meta-Analysis of Randomized Controlled Trials
por: He, Qiu-Lan, et al.
Publicado: (2014)

Effects of ulinastatin on renal perfusion evaluated by Doppler ultrasonography in a porcine model of septic shock
por: Hang, Chen-Chen, et al.
Publicado: (2021)

Effects of ulinastatin administered at different time points on the pathological morphologies of the lung tissues of rats with hyperthermia
por: QIN, ZAI-SHENG, et al.
Publicado: (2014)

Lack of Efficacy of Ulinastatin Therapy During Cardiopulmonary Bypass Surgery
por: Qiu, Yan, et al.
Publicado: (2015)

Ulinastatin attenuates oxidation, inflammation and neural apoptosis in the cerebral cortex of adult rats with ventricular fibrillation after cardiopulmonary resuscitation
por: Hu, Chun Lin, et al.
Publicado: (2013)

Associations of MMP-2 and MMP-9 gene polymorphism with ulinastatin efficacy in patients with severe acute pancreatitis
por: Zhen, Guo-Dong, et al.
Publicado: (2017)

Ancient origin of somatic and visceral neurons
por: Nomaksteinsky, Marc, et al.
Publicado: (2013)

Effect of ulinastatin on cytokine reaction during gastrectomy
por: Park, Ji Hun, et al.
Publicado: (2010)

The effect of ulinastatin on hemostasis in major orthopedic surgery
por: Lee, Jin Young, et al.
Publicado: (2010)

Effect of ulinastatin on the rocuronium-induced neuromuscular blockade
por: Kim, Min Soo, et al.
Publicado: (2012)

Impact of Ulinastatin on Outcomes in Acute Burns Patients
por: Abhyankar, Suhas Vidyadhar, et al.
Publicado: (2018)

Erratum to “Ulinastatin alleviates traumatic brain injury by reducing endothelin-1”
por: Liu, Ting, et al.
Publicado: (2021)

Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis
por: Guo, Jing, et al.
Publicado: (2022)

The effects of Xuebijing injection combined with ulinastatin as adjunctive therapy on sepsis: An overview of systematic review and meta-analysis
por: Zhong, Guofu, et al.
Publicado: (2022)

Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice
por: Huang, Shyh-Shyun, et al.
Publicado: (2011)

Protective effects of ulinastatin and methylprednisolone against radiation-induced lung injury in mice
por: Sun, Yu, et al.
Publicado: (2016)

Effects of ulinastatin and docetaxel on breast cancer invasion and expression of uPA, uPAR and ERK
por: Luo, Jie, et al.
Publicado: (2011)

Ulinastatin promotes macrophage efferocytosis and ameliorates lung inflammation via the ERK5/Mer signaling pathway
por: Li, Jinju, et al.
Publicado: (2022)

Ulinastatin: A Potential Alternative to Glucocorticoid in the Treatment of Severe Decompression Sickness
por: Meng, Wen-tao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_boirte7jo0o6iqkudup9d4k5uk