Gut microbes in cardiovascular diseases and their potential therapeutic applications

Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascula...

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Autores principales: Jin, Ling, Shi, Xiaoming, Yang, Jing, Zhao, Yangyu, Xue, Lixiang, Xu, Li, Cai, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106559/
https://www.ncbi.nlm.nih.gov/pubmed/32989686
http://dx.doi.org/10.1007/s13238-020-00785-9
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author Jin, Ling
Shi, Xiaoming
Yang, Jing
Zhao, Yangyu
Xue, Lixiang
Xu, Li
Cai, Jun
author_facet Jin, Ling
Shi, Xiaoming
Yang, Jing
Zhao, Yangyu
Xue, Lixiang
Xu, Li
Cai, Jun
author_sort Jin, Ling
collection PubMed
description Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the complex interplay between microbes, their metabolites, and the potential influence on the generation and development of CVDs. The therapeutic potential of using intestinal microbiomes to treat CVD is also discussed. It is quite possible that gut microbes may be used for clinical treatments of CVD in the near future.
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spelling pubmed-81065592021-05-11 Gut microbes in cardiovascular diseases and their potential therapeutic applications Jin, Ling Shi, Xiaoming Yang, Jing Zhao, Yangyu Xue, Lixiang Xu, Li Cai, Jun Protein Cell Review Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the complex interplay between microbes, their metabolites, and the potential influence on the generation and development of CVDs. The therapeutic potential of using intestinal microbiomes to treat CVD is also discussed. It is quite possible that gut microbes may be used for clinical treatments of CVD in the near future. Higher Education Press 2020-09-28 2021-05 /pmc/articles/PMC8106559/ /pubmed/32989686 http://dx.doi.org/10.1007/s13238-020-00785-9 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Jin, Ling
Shi, Xiaoming
Yang, Jing
Zhao, Yangyu
Xue, Lixiang
Xu, Li
Cai, Jun
Gut microbes in cardiovascular diseases and their potential therapeutic applications
title Gut microbes in cardiovascular diseases and their potential therapeutic applications
title_full Gut microbes in cardiovascular diseases and their potential therapeutic applications
title_fullStr Gut microbes in cardiovascular diseases and their potential therapeutic applications
title_full_unstemmed Gut microbes in cardiovascular diseases and their potential therapeutic applications
title_short Gut microbes in cardiovascular diseases and their potential therapeutic applications
title_sort gut microbes in cardiovascular diseases and their potential therapeutic applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106559/
https://www.ncbi.nlm.nih.gov/pubmed/32989686
http://dx.doi.org/10.1007/s13238-020-00785-9
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