Dexmedetomidine alleviates pulmonary edema through the epithelial sodium channel (ENaC) via the PI3K/Akt/Nedd4-2 pathway in LPS-induced acute lung injury

Dexmedetomidine (Dex), a highly selective α(2)-adrenergic receptor (α(2)AR) agonist, has an anti-inflammatory property and can alleviate pulmonary edema in lipopolysaccharide (LPS)-induced acute lung injury (ALI), but the mechanism is still unclear. In this study, we attempted to investigate the eff...

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Detalles Bibliográficos
Autores principales: Jiang, Yuanxu, Xia, Mingzhu, Xu, Jing, Huang, Qiang, Dai, Zhongliang, Zhang, Xueping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106593/
https://www.ncbi.nlm.nih.gov/pubmed/33641076
http://dx.doi.org/10.1007/s12026-021-09176-6

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