At the heart of mitochondrial quality control: many roads to the top

Mitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus...

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Detalles Bibliográficos
Autores principales: Gottlieb, Roberta A., Piplani, Honit, Sin, Jon, Sawaged, Savannah, Hamid, Syed M., Taylor, David J., de Freitas Germano, Juliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106602/
https://www.ncbi.nlm.nih.gov/pubmed/33544154
http://dx.doi.org/10.1007/s00018-021-03772-3
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author Gottlieb, Roberta A.
Piplani, Honit
Sin, Jon
Sawaged, Savannah
Hamid, Syed M.
Taylor, David J.
de Freitas Germano, Juliana
author_facet Gottlieb, Roberta A.
Piplani, Honit
Sin, Jon
Sawaged, Savannah
Hamid, Syed M.
Taylor, David J.
de Freitas Germano, Juliana
author_sort Gottlieb, Roberta A.
collection PubMed
description Mitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control including maintenance of mtDNA and the mitochondrial unfolded protein response, particularly in the context of the heart.
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spelling pubmed-81066022021-05-24 At the heart of mitochondrial quality control: many roads to the top Gottlieb, Roberta A. Piplani, Honit Sin, Jon Sawaged, Savannah Hamid, Syed M. Taylor, David J. de Freitas Germano, Juliana Cell Mol Life Sci Review Mitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control including maintenance of mtDNA and the mitochondrial unfolded protein response, particularly in the context of the heart. Springer International Publishing 2021-02-05 2021 /pmc/articles/PMC8106602/ /pubmed/33544154 http://dx.doi.org/10.1007/s00018-021-03772-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Gottlieb, Roberta A.
Piplani, Honit
Sin, Jon
Sawaged, Savannah
Hamid, Syed M.
Taylor, David J.
de Freitas Germano, Juliana
At the heart of mitochondrial quality control: many roads to the top
title At the heart of mitochondrial quality control: many roads to the top
title_full At the heart of mitochondrial quality control: many roads to the top
title_fullStr At the heart of mitochondrial quality control: many roads to the top
title_full_unstemmed At the heart of mitochondrial quality control: many roads to the top
title_short At the heart of mitochondrial quality control: many roads to the top
title_sort at the heart of mitochondrial quality control: many roads to the top
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106602/
https://www.ncbi.nlm.nih.gov/pubmed/33544154
http://dx.doi.org/10.1007/s00018-021-03772-3
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