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Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release. Here, we clarify the ambiguous role of the related family member gasdermin E (GSDME) in this process. Inflammasome stimulation in GSD...

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Detalles Bibliográficos
Autores principales:	Zhou, Bowen, Abbott, Derek W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106763/ https://www.ncbi.nlm.nih.gov/pubmed/33852854 http://dx.doi.org/10.1016/j.celrep.2021.108998

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