Cargando…

A molecular basis for neurofibroma-associated skeletal manifestations in NF1

PURPOSE: Plexiform neurofibromas (NF) develop in children with Neurofibromatosis Type 1 (NF1) and can be associated with several skeletal co-morbidities. Preclinical mouse studies revealed Nf1 deficiency in osteoprogenitor cells disrupts, in a MEK-dependent manner, pyrophosphate (PPi) homeostasis an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Yun, Gross, Andrea, Dombi, Eva, Pemov, Alex, Choi, Kwangmin, Chaney, Katherine, Rhodes, Steven D., Angus, Steven P, Sciaky, Noah, Clapp, D Wade, Ratner, Nancy, Widemann, Brigitte C, Rios, Jonathan J, Elefteriou, Florent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106869/ https://www.ncbi.nlm.nih.gov/pubmed/32601387 http://dx.doi.org/10.1038/s41436-020-0885-3

Ejemplares similares

STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma
por: Fletcher, Jonathan S., et al.
Publicado: (2018)

Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1
por: Nguyen, Rosa, et al.
Publicado: (2012)

MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK
por: Na, Youjin, et al.
Publicado: (2020)

Clinical trial design for cutaneous neurofibromas
por: Cannon, Ashley, et al.
Publicado: (2018)

Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment
por: Kershner, Leah J., et al.
Publicado: (2022)

Creating a comprehensive research strategy for cutaneous neurofibromas
por: Blakeley, Jaishri O., et al.
Publicado: (2018)

An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system
por: Choi, Kwangmin, et al.
Publicado: (2017)

NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas
por: Weiss, Brian D., et al.
Publicado: (2021)

NFB-17. MEK INHIBITOR BINIMETINIB SHOWS CLINICAL ACTIVITY IN CHILDREN WITH NEUROFIBROMATOSIS TYPE 1- ASSOCIATED PLEXIFORM NEUROFIBROMAS: A REPORT FROM PNOC AND THE NF CLINICAL TRIALS CONSORTIUM
por: Mueller, Sabine, et al.
Publicado: (2020)

Solitary Neurofibroma over Lower Lip: A Rare Manifestation
por: Jartarkar, Shishira R., et al.
Publicado: (2022)

After Nf1 loss in Schwann cells, inflammation drives neurofibroma formation
por: Fletcher, Jonathan S, et al.
Publicado: (2019)

Giant Plexiform Neurofibroma of the Perineum and Pelvic Cavity Manifesting as Segmental Neurofibromatosis
por: Park, Myeong Jin, et al.
Publicado: (2019)

Demographic and Disease-Related Predictors of Socioemotional Development in Children with Neurofibromatosis Type 1 and Plexiform Neurofibromas: An Exploratory Study
por: Hou, Yang, et al.
Publicado: (2022)

Pelvic Neurofibroma
por: Bakhshi, Girish D., et al.
Publicado: (2014)

Irradiation of Nf1 mutant mouse models of spinal plexiform neurofibromas drives pathologic progression and decreases survival
por: Laurent, Danny, et al.
Publicado: (2021)

Role of sympathetic nerves in the establishment of metastatic breast cancer cells in bone
por: Elefteriou, Florent
Publicado: (2016)

Ossifying Subperiosteal Hematoma Caused by a Plexiform Neurofibroma
por: Van den Berge, Steven, et al.
Publicado: (2020)

Neurofibroma of the Palate
por: Bharath, Tirumalasetty Sreenivasa, et al.
Publicado: (2014)

Neurofibromas on the Hands
por: Behrens, Joseph, et al.
Publicado: (2018)

Mediastinal Neurofibroma
Publicado: (1936)

Classical neurofibroma
por: Harjpal, Pallavi Lalchand, et al.
Publicado: (2021)

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors()
por: Patel, Ami V., et al.
Publicado: (2016)

Plexiform Neurofibroma in the Axilla with Intraosseous Neurofibroma in the Humerus in Neurofibromatosis 5
por: Khaladkar, Sanjay Mhalasakant, et al.
Publicado: (2018)

iGEAK: an interactive gene expression analysis kit for seamless workflow using the R/shiny platform
por: Choi, Kwangmin, et al.
Publicado: (2019)

Radiation Therapy in Management of Sporadic and Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors
por: Kahn, Jenna, et al.
Publicado: (2014)

Mechanisms Supporting the Use of Beta-Blockers for the Management of Breast Cancer Bone Metastasis
por: Madel, Maria-Bernadette, et al.
Publicado: (2021)

Cervical intramedullary neurofibroma.
por: Sharma, V., et al.
Publicado: (1990)

Large Neurofibroma of the Face
por: Kotamarti, Vasanth S., et al.
Publicado: (2015)

Hybrid Neurofibroma-Schwannoma
por: Hussain, Namath S, et al.
Publicado: (2016)

Eruptive neurofibromas in pregnancy
por: Xiong, Michael, et al.
Publicado: (2014)

Solitary neurofibroma of the breast
por: Thompson, Sherry, et al.
Publicado: (2015)

Huge neurofibroma of the scalp
por: Şimşek, Muhammed Eren, et al.
Publicado: (2014)

Diffuse neurofibroma of scalp
por: Kumar, Sushil, et al.
Publicado: (2014)

An isolated colonic neurofibroma
por: Bilal, Mohammad, et al.
Publicado: (2016)

Oral plexiform neurofibroma
por: Wu, Yu-Hsueh, et al.
Publicado: (2016)

Solitary neurofibroma of the heart
por: Li, Pei Jing, et al.
Publicado: (2020)

Eruptive Neurofibromas in Pregnancy
por: Yahya, Husain, et al.
Publicado: (2020)

Solitary neurofibroma of the palate,
por: Costa, Fábio Wildson Gurgel, et al.
Publicado: (2014)

Giant Pelvic Neurofibroma in Patient with Plexiform Sciatic Neurofibroma and Neurofibromatosis Type 1
por: Temelkova, Ivanka, et al.
Publicado: (2019)

Shared mechanisms: osteoporosis and Alzheimer’s disease?
por: Dengler-Crish, Christine M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7ci8b4si79n5prujjbv9tjqr44