5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer’s disease

5-hydroxymethylcytosine (5hmC) undergoes dynamic changes during mammalian brain development, and its dysregulation is associated with Alzheimer’s disease (AD). The dynamics of 5hmC during early human brain development and how they contribute to AD pathologies remain largely unexplored. We generate 5...

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Detalles Bibliográficos
Autores principales: Kuehner, Janise N., Chen, Junyu, Bruggeman, Emily C., Wang, Feng, Li, Yangping, Xu, Chongchong, McEachin, Zachary T., Li, Ziyi, Chen, Li, Hales, Chadwick M., Wen, Zhexing, Yang, Jingjing, Yao, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106871/
https://www.ncbi.nlm.nih.gov/pubmed/33910000
http://dx.doi.org/10.1016/j.celrep.2021.109042

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